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UTP15 - UTP15 small subunit processome component Gene

Also Known as NET21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84135

About UTP15

Cytogenetic location: 5q13.2 Genomic coordinates (GRCh38): 5:73,565,741-73,583,380 (from NCBI)

This gene has 8 transcripts (splice variants) and 203 orthologues. Ubiquitous expression in bone marrow (RPKM 3.2), thyroid (RPKM 2.7) and 25 other tissues.

Summary

Enables RNA binding activity. Involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Located in endoplasmic reticulum and fibrillar center. [provided by Alliance of Genome Resources, Apr 2022]

UTP15 Products (3)

mRNA	Protein	Name
NM_001284430.1	NP_001271359.1	U3 small nucleolar RNA-associated protein 15 homolog isoform 2
NM_001284431.1	NP_001271360.1	U3 small nucleolar RNA-associated protein 15 homolog isoform 3
NM_032175.4	NP_115551.2	U3 small nucleolar RNA-associated protein 15 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22916032	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of rRNA processing	IMP IMP: Inferred from mutant phenotype	17699751	GOA
involved in positive regulation of transcription by RNA polymerase I	IMP IMP: Inferred from mutant phenotype	17699751	GOA
involved in ribosomal small subunit biogenesis	IDA IDA: Inferred from direct assay	34516797	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in fibrillar center	IDA IDA: Inferred from direct assay	24219289	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	24219289	GOA
part of small-subunit processome	IDA IDA: Inferred from direct assay	34516797	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UTP15 Protein Structure

WD40

UTP15_C

0
100
200
300
400
518 a.a.

Protein Preferred Names	Protein Names
U3 small nucleolar RNA-associated protein 15 homolog	Src-associated protein SAW

Related Diseases

Diseases	Alias
Branchiooculofacial Syndrome	Branchio-Oculo-Facial Syndrome BOFS Bof Syndrome Hemangiomatous Branchial Clefts-Lip Pseudocleft Syndrome Lip Pseudocleft-Hemangiomatous Branchial Cyst Syndrome Branchial Clefts With Characteristic Facies, Growth Retardation, Imperforate Nasolacrimal Duct, And Premature Aging Branchial Clefts With Characteristic Facies Growth Retardation Imperforate Nasolacrimal Duct And Premature Aging Bofs Syndrome Lip Pseudocleft-Hemagiomatous Branchial Cyst Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107372S4	Uridine triphosphate-15N2 dilithium		98.0%	Unkown
HY-RS15576	UTP15 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	UTP15	VGNC	VGNC:79539
Canis familiaris	UTP15	VGNC	VGNC:48209
Rattus norvegicus	UTP15	RGD	RGD:1310992
Bos taurus	UTP15	VGNC	VGNC:36742
Mus musculus	UTP15	MGD	MGI:2145443
Felis catus	UTP15	VGNC	VGNC:66902
Others	UTP15	NCBI