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SLC37A3 - solute carrier family 37 member 3 Gene

Also Known as SPX3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84255

About SLC37A3

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,333,752-140,398,530 (from NCBI)

This gene has 28 transcripts (splice variants), 295 orthologues and 12 paralogues. Ubiquitous expression in endometrium (RPKM 19.0), thyroid (RPKM 9.8) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in carbohydrate transport and transmembrane transport. Is integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC37A3 Products (9)

mRNA	Protein	Name
NM_001287498.2	NP_001274427.1	sugar phosphate exchanger 3 isoform 3
NM_001363373.1	NP_001350302.1	sugar phosphate exchanger 3 isoform 4
NM_001363374.1	NP_001350303.1	sugar phosphate exchanger 3 isoform 5
NM_001363375.1	NP_001350304.1	sugar phosphate exchanger 3 isoform 6
NM_001363376.1	NP_001350305.1	sugar phosphate exchanger 3 isoform 7
NM_001363377.1	NP_001350306.1	sugar phosphate exchanger 3 isoform 8
NM_001363378.1	NP_001350307.1	sugar phosphate exchanger 3 isoform 9
NM_032295.4	NP_115671.1	sugar phosphate exchanger 3 isoform 2
NM_207113.3	NP_996996.1	sugar phosphate exchanger 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables glucose 6-phosphate:phosphate antiporter activity	IDA IDA: Inferred from direct assay	21949678	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29745899	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	29745899	GOA

Biological Process GO Annotation	Evidence	References	Source
NOT involved in glucose-6-phosphate transport	IDA IDA: Inferred from direct assay	21949678	GOA
NOT involved in phosphate ion transmembrane transport	IDA IDA: Inferred from direct assay	21949678	GOA
involved in xenobiotic transmembrane transport	IDA IDA: Inferred from direct assay	29745899	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21949678	GOA
located in lysosomal membrane	IDA IDA: Inferred from direct assay	29745899	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC37A3 Protein Structure

MFS_1

0
100
200
300
400
494 a.a.

Protein Preferred Names	Protein Names
sugar phosphate exchanger 3	solute carrier family 37 (glycerol-3-phosphate transporter), member 3

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 8	Neurosensory Nonsyndromic Recessive Deafness 8 DFNB8 Dfnb10 Deafness, Autosomal Recessive 10 Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8 Nsrd8 Autosomal Recessive Nonsyndromic Deafness 8 Deafness, Autosomal Recessive 8/10 Autosomal Recessive Deafness 10 Autosomal Recessive Deafness 8 Childhood-Onset Neurosensory Autosomal Recessive Deafness 8 Nrsd8 Deafness, Autosomal Recessive, 8 Childhood-Onset Neurosensory Deafness Autosomal Recessive 8 Deafness Autosomal Recessive 10 Deafness Autosomal Recessive 8/10 Deafness Neurosensory Autosomal Recessive 8 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8 Deafness, Autosomal Recessive, Type 8/10
Caffey Disease	Infantile Cortical Hyperostosis CAFYD Cortical Congenital Hyperostosis Caffey-Silverman Syndrome De Toni-Caffey Disease Hyperostosis Cortical Infantile Hyperostosis, Cortical, Congenital
Glycerol Kinase Deficiency	Hyperglycerolemia GKD Gk Deficiency Gk1 Deficiency Deficiency Of Glycerol Kinase Isolated Glycerol Kinase Deficiency Glycerol Kinase Deficiency, Adult Form Glycerol Kinase Deficiency, Juvenile Form Deficiency, Glycerol Kinase
Glycogen Storage Disease Ia	Von Gierke Disease Glycogen Storage Disease Type I Glycogen Storage Disease I Hepatorenal Form Of Glycogen Storage Disease Hepatorenal Glycogenosis Glucose-6-Phosphatase Deficiency Glycogen Storage Disease, Type I Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia GSD1A Gsd1 Von Gierke'S Disease Glycogen Storage Disease Type 1a Glycogen Storage Disease 1a Glucose-6-Phosphate Transport Defect Gsd Ia Deficiency Of Glucose-6-Phosphatase Glycogenosis Type I Glucose-6-Phosphatase Deficiency Glycogen Storage Disease Glycogenosis Type 1 Glucose-6-Phosphate Deficiency Gsd I Gsd Type I G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type Ia Gsd Type 1a Gsdia Glycogen Storage Disease Due To G6p Deficiency Type Ia Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia Glycogenosis Type Ia Gsd-Ia Storage Disease, Glycogen, Type 1a Glycogen Storage Disease Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13215	SLC37A3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC37A3	RGD	RGD:1310346
Canis familiaris	SLC37A3	VGNC	VGNC:46388
Mus musculus	SLC37A3	MGD	MGI:1919394
Felis catus	SLC37A3	VGNC	VGNC:80719
Bos taurus	SLC37A3	VGNC	VGNC:34844
Macaca mulatta	SLC37A3	VGNC	VGNC:81574