LZIC - leucine zipper and CTNNBIP1 domain containing Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84328

About LZIC

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:9,922,118-9,943,391 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 8.7), colon (RPKM 7.1) and 25 other tissues.

Summary

Predicted to enable beta-catenin binding activity. Predicted to be involved in response to ionizing radiation. [provided by Alliance of Genome Resources, Apr 2022]

LZIC Products (5)

mRNA Protein Name
NM_001316973.2 NP_001303902.1 protein LZIC isoform a
NM_001316974.2 NP_001303903.1 protein LZIC isoform b
NM_001316975.2 NP_001303904.1 protein LZIC isoform c
NM_001316976.2 NP_001303905.1 protein LZIC isoform d
NM_032368.5 NP_115744.2 protein LZIC isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LZIC Protein Structure

ICAT

ICAT: Beta-catenin-interacting protein ICAT (113 - 190)

  • 0
  • 100
  • 190 a.a.
Protein Preferred Names Protein Names

protein LZIC

  • leucine zipper and CTNNBIP1 domain-containing protein

LZIC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LZIC Q8WZA0 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
LZIC Q8WZA0 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
LZIC Q8WZA0 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
LZIC Q8WZA0 VCP Homo sapiens P55072
Y2H Pooling
32814053
Intra
LZIC Q8WZA0 VCP Homo sapiens P55072
Validated Y2H
32814053
Intra
LZIC Q8WZA0 VCP Homo sapiens P55072
Y2H Array
32814053
Intra
LZIC Q8WZA0 ZNF558 Homo sapiens Q96NG5
Y2H Prey Pooling
32296183
Intra
LZIC Q8WZA0 ZNF558 Homo sapiens Q96NG5
Validated Y2H
32296183
Intra
LZIC Q8WZA0 ZNF558 Homo sapiens Q96NG5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schnyder Corneal Dystrophy

  • Schnyder Crystalline Corneal Dystrophy

  • SCCD

  • Corneal Dystrophy, Crystalline, Of Schnyder

  • Corneal Dystrophy, Schnyder Type

  • Corneal Dystrophy Crystalline Of Schnyder

  • Crystalline Stromal Dystrophy

  • Hereditary Crystalline Stromal Dystrophy Of Schnyder

  • Scd

  • Corneal Dystrophy, Schnyder

  • Schnyder Crystalline Dystrophy Sine Crystals

  • Dystrophy, Corneal, Crystalline, Schnyder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07931 LZIC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LZIC VGNC VGNC:106811
Canis familiaris LZIC VGNC VGNC:42903
Felis catus LZIC VGNC VGNC:107578
Mus musculus LZIC MGD MGI:1916401
Macaca mulatta LZIC VGNC VGNC:74306
Rattus norvegicus LZIC RGD RGD:1309253
Others LZIC NCBI