HIRIP3 - HIRA interacting protein 3 Gene

Homo sapiens

Gene ID: 8479 | Gene type: protein coding

About HIRIP3

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,992,321-29,996,096 (from NCBI)

This gene has 7 transcripts (splice variants) and 178 orthologues. Broad expression in testis (RPKM 18.6), brain (RPKM 7.1) and 24 other tissues.

Summary

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

HIRIP3 Products(2)

mRNA	Protein	Name
NM_001197323.1	NP_001184252.1	HIRA-interacting protein 3 isoform 2
NM_003609.5	NP_003600.2	HIRA-interacting protein 3 isoform 1

HIRIP3 Protein Structure

CHZ

0
100
200
300
400
500
556 a.a.

Protein Preferred Names

Protein Names

HIRA-interacting protein 3

Related Diseases

Diseases

Alias

Schizophrenia 3

SCZD3	Schizophrenia Susceptibility Locus, Chromosome 6-Related
Schizophrenia 3 With Or Without An Affective Disorder

Chromosome 16p12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb

Chromosome 16p12.2-P11.2 Deletion Syndrome	16p11.2p12.2 Microdeletion Syndrome
16p11.2-P12.2 Microdeletion Syndrome	Del(16)(P11.2p12.2)
Monosomy 16p11.2p12.2	Chromosome Deletion Syndrome 16p12.2-P11.2

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06186	HIRIP3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HIRIP3	VGNC	VGNC:29862
Rattus norvegicus	HIRIP3	RGD	RGD:1306463
Felis catus	HIRIP3	VGNC	VGNC:67577
Mus musculus	HIRIP3	MGD	MGI:2142364
Canis familiaris	HIRIP3	VGNC	VGNC:41696
Macaca mulatta	HIRIP3	VGNC	VGNC:73473

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