HIRIP3 - HIRA interacting protein 3 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8479

About HIRIP3

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,992,321-29,996,096 (from NCBI)

This gene has 7 transcripts (splice variants) and 178 orthologues. Broad expression in testis (RPKM 18.6), brain (RPKM 7.1) and 24 other tissues.

Summary

The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

HIRIP3 Products (2)

mRNA	Protein	Name
NM_001197323.1	NP_001184252.1	HIRA-interacting protein 3 isoform 2
NM_003609.5	NP_003600.2	HIRA-interacting protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables H2A-H2B histone complex chaperone activity	IDA IDA: Inferred from direct assay	38334665	GOA
enables H2A-H2B histone complex chaperone activity	IMP IMP: Inferred from mutant phenotype	38334665	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9710638	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in chromatin organization	IDA IDA: Inferred from direct assay	38334665	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	17391060	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIRIP3 Protein Structure

CHZ

0
100
200
300
400
500
556 a.a.

Protein Preferred Names	Protein Names
HIRA-interacting protein 3

HIRIP3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	HIRIP3	Q9BW71	SGK2	Homo sapiens	Q9HBY8-2	Y2H Prey Pooling	32296183
Intra	HIRIP3	Q9BW71	SGK2	Homo sapiens	Q9HBY8-2	Y2H Array	32296183
Intra	HIRIP3	Q9BW71	SGK2	Homo sapiens	Q9HBY8-2	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia 3	SCZD3 Schizophrenia Susceptibility Locus, Chromosome 6-Related Schizophrenia 3 With Or Without An Affective Disorder
Chromosome 16p12.2-P11.2 Deletion Syndrome, 7.1- To 8.7-Mb	Chromosome 16p12.2-P11.2 Deletion Syndrome 16p11.2p12.2 Microdeletion Syndrome 16p11.2-P12.2 Microdeletion Syndrome Del(16)(P11.2p12.2) Monosomy 16p11.2p12.2 Chromosome Deletion Syndrome 16p12.2-P11.2
Velocardiofacial Syndrome	Shprintzen Syndrome VCFS Chromosome 22q11.2 Deletion Syndrome Vcf Syndrome Shprintzen Vcf Syndrome Vcf-Velocardiofacial Syndrome Velo-Cardio-Facial Syndrome Digeorge Syndrome 22q11 Deletion Syndrome Conotruncal Anomaly Face Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06186	HIRIP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HIRIP3	VGNC	VGNC:29862
Rattus norvegicus	HIRIP3	RGD	RGD:1306463
Felis catus	HIRIP3	VGNC	VGNC:67577
Mus musculus	HIRIP3	MGD	MGI:2142364
Canis familiaris	HIRIP3	VGNC	VGNC:41696
Macaca mulatta	HIRIP3	VGNC	VGNC:73473
Others	HIRIP3	NCBI