ATG4C - autophagy related 4C cysteine peptidase Gene

Also Known as APG4C; AUTL1; AUTL3; APG4-C; HsAPG4C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84938

About ATG4C

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,784,132-62,865,516 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.0), placenta (RPKM 3.4) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

ATG4C Products (2)

mRNA Protein Name
NM_032852.4 NP_116241.2 cysteine protease ATG4C
NM_178221.3 NP_835739.1 cysteine protease ATG4C

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
21177865 GOA
enables cysteine-type peptidase activity IDA
IDA: Inferred from direct assay
21177865 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IDA
IDA: Inferred from direct assay
21177865 GOA
involved in autophagy IDA
IDA: Inferred from direct assay
30661429 GOA
involved in protein delipidation IDA
IDA: Inferred from direct assay
29458288 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
21177865 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG4C Protein Structure

Peptidase_C54

Peptidase_C54: Peptidase family C54 (75 - 401)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 458 a.a.
Protein Preferred Names Protein Names

cysteine protease ATG4C

  • APG4 autophagy 4 homolog C

Recombinant ATG4C Proteins

Cat. No. Product Name Accession Purity
HY-P7619 ATG4C Protein, Human (His) Q96DT6 (M1-L458) ≥ 95%, as determined by reducing SDS-PAGE.

ATG4C Antibodies

Cat. No. Product Name Application Reactivity
HY-P80558 ATG4C Antibody (YA600) WB, IHC-P Human
HY-P80558A ATG4C Antibody (YA600)(PBS only) WB, IHC-P Human
HY-P83725 ATG4C Antibody (YA3456) WB, IP Human, Mouse, Rat
HY-P84726 ATG4C Antibody (YA4423) WB, ELISA Human
HY-P84726A ATG4C Antibody (YA4423)(PBS only) WB, ELISA Human

Related Diseases

Diseases Alias
Exhibitionism
Rem Sleep Behavior Disorder

  • Rapid Eye Movement Sleep Behavior Disorder

  • Rem Sleep Behaviour Disorder

  • Rapid Eye Movement Sleep Behaviour Disorder

  • Rem - [Rapid Eye Movement] Behaviour Disorder
Dependent Personality Disorder
Atypical Autism

  • Pdd
Paraphilia Disorder

  • Paraphilia

  • Paraphilias
Ceroid Lipofuscinosis, Neuronal, 1

  • Neuronal Ceroid Lipofuscinosis 1

  • CLN1

  • Infantile Neuronal Ceroid Lipofuscinosis

  • Cln1 Disease

  • Santavuori-Haltia Disease

  • Ceroid Lipofuscinosis, Neuronal, 1, Variable Age At Onset

  • Neuronal Ceroid Lipofuscinosis 1 Variable Age Of Onset

  • Ceroid Lipofuscinosis Neuronal 1

  • Cln1 Variable Age At Onset

  • Infantile Batten Disease

  • Neuronal Ceroid Lipofuscinosis, Infantile

  • Hagberg-Santavuori Disease

  • Incl

  • Juvenile Neuronal Ceroid Lipofuscinosis With Granular Osmiophilic Deposits

  • Neuronal Ceroid Lipofuscinosis With Variable Age At Onset

  • Santavuori Disease

  • Lipofuscinosis, Ceroid, Neuronal, Type 1

  • Ceroid Lipofuscinosis, Neuronal 1, Infantile
Vascular Parkinsonism
Sleep Disorder

  • Sleep Disorders

  • Non-Organic Sleep Disorder
Echolalia
Parkinson Disease, Late-Onset

  • Parkinson Disease

  • Parkinson'S Disease

  • PD

  • PARK

  • Parkinson Disease, Susceptibility To

  • Late Onset Parkinson'S Disease

  • Late Onset Parkinson Disease

  • Paralysis Agitans

  • Primary Parkinsonism

  • Idiopathic Parkinson Disease

  • Parkinson'S

  • Parkinson Disease, Late-Onset, Susceptibility To

  • Parkinson Disease, Age Of Onset, Modifier

  • Lewy Body Parkinson Disease

  • Idiopathic Parkinson'S Disease

  • Pd - [Parkinson Disease]

  • Parkinson Disease Nos

  • Parkinson, Nos

  • Primary Parkinson Disease
Movement Disease

  • Movement Disorders

  • Movement Disorder
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01150 ATG4C Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19174 Atg4c Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25663 Atg4c Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ATG4C VGNC VGNC:60004
Canis familiaris ATG4C VGNC VGNC:38224
Rattus norvegicus ATG4C RGD RGD:1598323
Mus musculus ATG4C MGD MGI:2651854
Macaca mulatta ATG4C VGNC VGNC:70079
Bos taurus ATG4C VGNC VGNC:26259
Others ATG4C NCBI