ATG4C - autophagy related 4C cysteine peptidase Gene

Homo sapiens

Also known as APG4C; AUTL1; AUTL3; APG4-C; HsAPG4C

Gene ID: 84938 | Gene type: protein coding

About ATG4C

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,784,132-62,865,516 (from NCBI)

This gene has 5 transcripts (splice variants), 208 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 4.0), placenta (RPKM 3.4) and 25 other tissues.

Summary

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of Autophagy have been described in some malignant tumors, and a role for Autophagy in controlling the unregulated cell growth linked to Cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008]

ATG4C Products(2)

mRNA	Protein	Name
NM_032852.4	NP_116241.2	cysteine protease ATG4C
NM_178221.3	NP_835739.1	cysteine protease ATG4C

ATG4C Protein Structure

Peptidase_C54

0
100
200
300
400
458 a.a.

Protein Preferred Names

Protein Names

cysteine protease ATG4C

APG4 autophagy 4 homolog C

Recombinant ATG4C Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7619	ATG4C Protein, Human (His)	Q96DT6 (M1-L458)	≥95%

Related Diseases

Diseases

Alias

Exhibitionism

Rem Sleep Behavior Disorder

Rapid Eye Movement Sleep Behavior Disorder	Rem Sleep Behaviour Disorder
Rapid Eye Movement Sleep Behaviour Disorder	Rem - [Rapid Eye Movement] Behaviour Disorder

Dependent Personality Disorder

Atypical Autism

Pdd

Paraphilia Disorder

Paraphilia

Paraphilias

Ceroid Lipofuscinosis, Neuronal, 1

Neuronal Ceroid Lipofuscinosis 1	CLN1
Infantile Neuronal Ceroid Lipofuscinosis	Cln1 Disease
Santavuori-Haltia Disease	Ceroid Lipofuscinosis, Neuronal, 1, Variable Age At Onset
Neuronal Ceroid Lipofuscinosis 1 Variable Age Of Onset	Ceroid Lipofuscinosis Neuronal 1
Cln1 Variable Age At Onset	Infantile Batten Disease
Neuronal Ceroid Lipofuscinosis, Infantile	Hagberg-Santavuori Disease
Incl	Juvenile Neuronal Ceroid Lipofuscinosis With Granular Osmiophilic Deposits
Neuronal Ceroid Lipofuscinosis With Variable Age At Onset	Santavuori Disease
Lipofuscinosis, Ceroid, Neuronal, Type 1	Ceroid Lipofuscinosis, Neuronal 1, Infantile

Vascular Parkinsonism

Sleep Disorder

Sleep Disorders

Non-Organic Sleep Disorder

Echolalia

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Movement Disease

Movement Disorders

Movement Disorder

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01150	ATG4C Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ATG4C	VGNC	VGNC:60004
Canis familiaris	ATG4C	VGNC	VGNC:38224
Rattus norvegicus	ATG4C	RGD	RGD:1598323
Mus musculus	ATG4C	MGD	MGI:2651854
Macaca mulatta	ATG4C	VGNC	VGNC:70079
Bos taurus	ATG4C	VGNC	VGNC:26259
Others	ATG4C	NCBI

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