country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

MPND - MPN domain containing Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84954

About MPND

This gene has 8 transcripts (splice variants), 184 orthologues and 3 paralogues. Ubiquitous expression in colon (RPKM 12.4), duodenum (RPKM 11.4) and 25 other tissues.

Summary

Predicted to enable histone binding activity; peptidase activity; and transcription coactivator activity. Predicted to be involved in chromatin remodeling and positive regulation of transcription by RNA polymerase II. [provided by Alliance of Genome Resources, Apr 2022]

MPND Products (3)

mRNA	Protein	Name
NM_001159846.3	NP_001153318.1	MPN domain-containing protein isoform 2
NM_001300862.2	NP_001287791.1	MPN domain-containing protein isoform 3
NM_032868.6	NP_116257.2	MPN domain-containing protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPND Protein Structure

JAB

0
100
200
300
400
471 a.a.

Protein Preferred Names	Protein Names
MPN domain-containing protein

MPND Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Y2H Pooling	32814053
Intra	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Validated Y2H	32814053
Intra	MPND	Q8N594	JPH3	Homo sapiens	Q8WXH2	Y2H Array	32814053
Intra	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	MPND	Q8N594	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	MPND	Q8N594	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	MPND	Q8N594	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	MPND	Q8N594	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	MPND	Q8N594	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	MPND	Q8N594	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
Intra	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	MPND	Q8N594	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Amyloidosis, Hereditary, Transthyretin-Related	Transthyretin Amyloidosis Familial Amyloid Polyneuropathy Ttr Amyloid Neuropathy Transthyretin Amyloid Neuropathy Transthyretin Amyloid Polyneuropathy Fap Familial Transthyretin Amyloidosis Amyloidosis Transthyretin Related Type I Familial Amyloid Polyneuropathy Familial Amyloid Polyneuropathy Type I Attrv122i Amyloidosis Hereditary Amyloidosis, Transthyretin-Related Amyloid Polyneuropathy, Familial Attr Amyloidosis Attrm Amyloidosis Corino De Andrade'S Disease Paramyloidosis Transthyretin-Related Hereditary Amyloidosis Ttr Amyloidosis Hereditary Attr Amyloidosis Portuguese Polyneuritic Amyloidosis Portuguese Type Familial Amyloid Neuropathy Swiss Type Amyloid Polyneuropathy Type Ii Familial Amyloid Polyneuropathy Attrv30m Amyloidosis Attrv30m-Related Amyloidosis Familial Amyloid Polyneuropathy, Portuguese-Swedish-Japanese Type Attr Cardiomyopathy Attrv122i-Related Amyloidosis Ttr-Related Amyloid Cardiomyopathy Ttr-Related Cardiac Amyloidosis Transthyretin Amyloid Cardiopathy Transthyretin-Related Familial Amyloid Cardiomyopathy Amyloidosis, Transthyretin-Related AMYL-TTR Amyloidosis I Amyloidosis Ohio Type Amyloidosis Type 7 Amyloidosis Vii Amyloid Polyneuropathy Attr Familial Amyloid Polyneuropathy Type Ii Hereditary Amyloidosis Transthyretin-Related Leptomeningeal Amyloidosis Meningocerebrovascular Amyloidosis Oculoleptomeningeal Amyloidosis Familial Amyloid Polyneuropathies Amyloidosis, Leptomeningeal Senile Cardiac Amyloidosis Amyloid Neuropathies, Familial Danish Type Familial Amyloid Cardiomyopathy Familial Amyloid Neuropathy, Portuguese Type Amyloid Polyneuropathy, Swiss Type Hereditary Oculoleptomeningeal Amyloid Angiopathy Amyloid Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08620	MPND Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18837	Psmb6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22239	Mpnd Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28761	Mpnd Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MPND	VGNC	VGNC:31580
Canis familiaris	MPND	VGNC	VGNC:43340
Felis catus	MPND	VGNC	VGNC:63573
Macaca mulatta	MPND	VGNC	VGNC:74831
Rattus norvegicus	MPND	RGD	RGD:1589335
Mus musculus	MPND	MGD	MGI:1915297
Others	MPND	NCBI