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UNC5C - unc-5 netrin receptor C Gene

Also Known as UNC5H3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8633

About UNC5C

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:95,162,504-95,548,973 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues.

Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for Others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

UNC5C Products (1)

mRNA	Protein	Name
NM_003728.4	NP_003719.3	netrin receptor UNC5C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22685302	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	27068745	GOA
enables tubulin binding	IPI IPI: Inferred from physical interaction	28483977	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in dorsal root ganglion development	IDA IDA: Inferred from direct assay	28483977	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	25419706	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UNC5C Protein Structure

I-set

TSP_1

ZU5

Death

0
200
400
600
800
931 a.a.

Protein Preferred Names	Protein Names
netrin receptor UNC5C	protein unc-5 homolog 3

UNC5C Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	UNC5C	O95185	TUBB3	Homo sapiens	Q13509	Pull Down	28483977
Intra	UNC5C	O95185	TUBB3	Homo sapiens	Q13509	Anti Tag CoIP	28483977

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Immunodeficiency 43	Hypoproteinemia, Hypercatabolic IMD43 Beta-2-Microglobulin Deficiency B2m Deficiency Hypercatabolic Hypoproteinemia
Glass Syndrome	Chromosome 2q32-Q33 Deletion Syndrome Satb2-Associated Syndrome 2q33.1 Microdeletion Syndrome Sas 2q32-Q33 Microdeletion Syndrome 2q32q33 Microdeletion Syndrome Monosomy 2q32 Monosomy 2q32-Q33 Monosomy 2q32q33 2q32 Deletion Syndrome Del(2)(Q32) Del(2)(Q32q33) GLASS 2q32q33 Microdeletion Syndromes Satb2 Syndrome Satb2-Associated Syndrome Due To A Chromosomal Rearrangement Del(2)(Q33.1) Monosomy 2q33.1 Satb2-Associated Syndrome Due To A Pathogenic Variant Satb2-Associated Syndrome Due To A Point Mutation Satb2 Associated Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3882	Fmoc-Ala-Glu-Gln-Lys-NH2		99.26%	Unkown
HY-RS15473	UNC5C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	UNC5C	VGNC	VGNC:66830
Macaca mulatta	UNC5C	VGNC	VGNC:78723
Bos taurus	UNC5C	VGNC	VGNC:36672
Mus musculus	UNC5C	MGD	MGI:1095412
Rattus norvegicus	UNC5C	RGD	RGD:735109
Canis familiaris	UNC5C	VGNC	VGNC:48141
Others	UNC5C	NCBI