1. Gene
  2. UNC5C - unc-5 netrin receptor C Gene

UNC5C - unc-5 netrin receptor C Gene

Homo sapiens

Also known as UNC5H3

Gene ID: 8633 | Gene type: protein coding

About UNC5C

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:95,162,504-95,548,973 (from NCBI)

This gene has 5 transcripts (splice variants), 277 orthologues and 4 paralogues. Broad expression in thyroid (RPKM 2.7), adrenal (RPKM 2.7) and 21 other tissues.

Summary

This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for Others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region. [provided by RefSeq, Jul 2008]

UNC5C Products(1)

mRNA Protein Name
NM_003728.4 NP_003719.3 netrin receptor UNC5C precursor

UNC5C Protein Structure

I-set

I-set: Immunoglobulin I-set domain (168 - 257)

TSP_1

TSP_1: Thrombospondin type 1 domain (264 - 310)

TSP_1

TSP_1: Thrombospondin type 1 domain (318 - 367)

ZU5

ZU5: ZU5 domain (529 - 629)

Death

Death: Death domain (850 - 926)

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  • 931 a.a.
Protein Preferred Names Protein Names

netrin receptor UNC5C

protein unc-5 homolog 3

Related Diseases

Diseases Alias
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

Immunodeficiency 43

Hypoproteinemia, Hypercatabolic

IMD43

Beta-2-Microglobulin Deficiency

B2m Deficiency

Hypercatabolic Hypoproteinemia

Glass Syndrome

Chromosome 2q32-Q33 Deletion Syndrome

Satb2-Associated Syndrome

2q33.1 Microdeletion Syndrome

Sas

2q32-Q33 Microdeletion Syndrome

2q32q33 Microdeletion Syndrome

Monosomy 2q32

Monosomy 2q32-Q33

Monosomy 2q32q33

2q32 Deletion Syndrome

Del(2)(Q32)

Del(2)(Q32q33)

GLASS

2q32q33 Microdeletion Syndromes

Satb2 Syndrome

Satb2-Associated Syndrome Due To A Chromosomal Rearrangement

Del(2)(Q33.1)

Monosomy 2q33.1

Satb2-Associated Syndrome Due To A Pathogenic Variant

Satb2-Associated Syndrome Due To A Point Mutation

Satb2 Associated Disorder

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus UNC5C VGNC VGNC:66830
Macaca mulatta UNC5C VGNC VGNC:78723
Bos taurus UNC5C VGNC VGNC:36672
Mus musculus UNC5C MGD MGI:1095412
Rattus norvegicus UNC5C RGD RGD:735109
Canis familiaris UNC5C VGNC VGNC:48141