RNASET2 - ribonuclease T2 Gene

Homo sapiens

Also known as RNASE6PL; bA514O12.3

Gene ID: 8635 | Gene type: protein coding

About RNASET2

Cytogenetic location: 6q27 Genomic coordinates (GRCh38): 6:166,922,113-166,956,550 (from NCBI)

This gene has 22 transcripts (splice variants), 203 orthologues and is associated with 3 phenotypes. Broad expression in spleen (RPKM 93.0), colon (RPKM 39.0) and 24 other tissues.

Summary

This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]

RNASET2 Products(1)

mRNA	Protein	Name
NM_003730.6	NP_003721.2	ribonuclease T2 precursor

RNASET2 Protein Structure

Ribonuclease_T2

0
100
200
256 a.a.

Protein Preferred Names

Protein Names

ribonuclease T2

ribonuclease 6

Recombinant RNASET2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71015	RNASET2 Protein, Human (HEK293, His)	O00584 (D25-H256)	≥95%
HY-P76006	RNASET2 Protein, Human (sf9, His)	O00584 (D25-H256)	≥95%

Related Diseases

Diseases

Alias

Leukoencephalopathy, Cystic, Without Megalencephaly

Cystic Leukoencephalopathy Without Megalencephaly	Rnaset2-Deficient Cystic Leukoencephalopathy
Rnase T2-Deficient Leukoencephalopathy	Clwm
Leukoencephalopathy With Bilateral Anterior Temporal Lobe Cysts	Infantile-Onset Rnaset2 Deficient Cystic Leukoencephalopathy
Lbatc	LCWM

Pseudo-Torch Syndrome 1

Pseudo-Torch Syndrome	Band-Like Calcification With Simplified Gyration And Polymicrogyria
Blcpmg	PTORCH1
Baraitser-Brett-Piesowicz Syndrome	Baraitser-Reardon Syndrome
Bilateral Band-Like Calcification With Polymicrogyria	Blc-Pmg
Microcephaly-Intracranial Calcification-Intellectual Disability Syndrome	Congenital Intrauterine Infection-Like Syndrome
Baraitser Brett Piesowicz Syndrome	Microcephaly - Intracranial Calcification - Intellectual Disability

Megalencephaly

Macroencephaly

Macrencephaly

Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome	Cree Encephalitis
Aicardi-Goutières Syndrome	Encephalopathy With Basal Ganglia Calcification
Ags	Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid
Pseudotoxoplasmosis Syndrome	Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis
Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis	Aicardi-Goutieres Syndrome 1

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12030	RNASET2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RNASET2	VGNC	VGNC:102504
Rattus norvegicus	RNASET2	RGD	RGD:1309918
Macaca mulatta	RNASET2	VGNC	VGNC:99439
Others	RNASET2	NCBI

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