PEX11A - peroxisomal biogenesis factor 11 alpha Gene

Also Known as PMP28; hsPEX11p; PEX11alpha; PEX11-ALPHA

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8800

About PEX11A

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,681,535-89,690,754 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 14.4), prostate (RPKM 9.1) and 24 other tissues.

Summary

This gene is a member of the PEX11 family, which is composed of membrane elongation factors involved in regulation of peroxisome maintenance and proliferation. This gene product interacts with peroxisomal membrane protein 19 and may respond to outside stimuli to increase peroxisome abundance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]

PEX11A Products (3)

mRNA Protein Name
NM_001271572.2 NP_001258501.1 peroxisomal membrane protein 11A isoform 2
NM_001271573.2 NP_001258502.1 peroxisomal membrane protein 11A isoform 3
NM_003847.3 NP_003838.1 peroxisomal membrane protein 11A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
20826455 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20826455 GOA
Biological Process GO Annotation Evidence References Source
involved in peroxisome fission IDA
IDA: Inferred from direct assay
20826455 GOA
involved in peroxisome organization IMP
IMP: Inferred from mutant phenotype
9792670 GOA
involved in regulation of peroxisome size IDA
IDA: Inferred from direct assay
20826455 GOA
involved in signal transduction IMP
IMP: Inferred from mutant phenotype
9792670 GOA
Cellular Component GO Annotation Evidence References Source
located in peroxisomal membrane IDA
IDA: Inferred from direct assay
9714566 GOA
located in peroxisome IDA
IDA: Inferred from direct assay
9922452 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20826455 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PEX11A Protein Structure

PEX11

PEX11: Peroxisomal biogenesis factor 11 (PEX11) (1 - 237)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

peroxisomal membrane protein 11A

  • 28 kDa peroxisomal integral membrane protein

Recombinant PEX11A Proteins

Cat. No. Product Name Accession Purity
HY-P77133 PEX11A Protein, Human (HEK293, Fc) O75192 (R106-P219) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Peroxisomal Acyl-Coa Oxidase Deficiency

  • Pseudoneonatal Adrenoleukodystrophy

  • Straight-Chain Acyl-Coa Oxidase Deficiency

  • Pseudoadrenoleukodystrophy

  • PSEUDO-NALD

  • Pseudo-Neonatal Adrenoleukodystrophy

  • Acyl-Coa Oxidase Deficiency

  • Peroxisomal Acyl-Coenzyme A Oxidase

  • Acyl-Coenzyme A Oxidase Deficiency

  • Adrenoleukodystrophy, Pseudoneonatal

  • Deficiency, Peroxisomal Acyl-Coa Oxidase
Peroxisomal Biogenesis Disorder

  • Zellweger Spectrum Disorders

  • Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum

  • Disorders Of Peroxisome Biogenesis

  • Zellweger Spectrum

  • Zellweger Syndrome Spectrum

  • Peroxisomal Biogenesis Disorders

  • Pbd, Zss

  • Pbd-Zsd

  • Pbd-Zss

  • Pbd-Zellweger Spectrum Disorder

  • Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum

  • Peroxisome Biogenesis Disorder

  • Peroxisome Biogenesis Disorder Spectrum

  • Peroxisome Biogenesis Disorders

  • Zellweger Spectrum Disorder

  • Hyperpipecolic Acidaemia
Refsum Disease, Classic

  • Refsum Disease

  • Heredopathia Atactica Polyneuritiformis

  • Phytanic Acid Oxidase Deficiency

  • Hmsn Iv

  • Refsum Disease, Adult, 1

  • Refsum'S Disease

  • Phytanic Acid Storage Disease

  • Hereditary Motor And Sensory Neuropathy Iv

  • Hmsn4

  • Hmsn Type Iv

  • Hmsn 4

  • Adult Refsum Disease

  • Classic Refsum Disease

  • Hereditary Motor And Sensory Neuropathy Type Iv

  • Refsum Syndrome

  • Hsmn Iv

  • Disorder Of Cornification 11

  • Doc 11

  • Hereditary Sensory And Motor Neuropathy Type 4

  • Hypertrophic Neuropathy Of Refsum

  • Ard

  • Crd

  • Hereditary Motor And Sensory Neuropathy Type 4

  • Phytanic-Coa Hydroxylase Deficiency

  • RD
Peroxisomal Disease

  • Peroxisomal Disorder

  • Peroxisomal Disorders

  • Peroxisomal Defects
Acatalasemia

  • Acatalasia

  • Catalase Deficiency

  • Deficiency Of Catalase

  • ACATLAS

  • Takahara'S Disease

  • Takahara Disease
Peroxisome Biogenesis Disorder 1b

  • Peroxisome Biogenesis Disorder

  • Infantile Refsum Disease

  • Infantile Phytanic Acid Storage Disease

  • PBD1B

  • Refsum Disease, Infantile

  • Adrenoleukodystrophy, Autosomal Neonatal

  • Ird

  • Mild Pbd-Zsd

  • Mild Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Pbd-Zsd

  • Peroxisome Biogenesis Disorder Spectrum

  • Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

  • Autosomal Neonatal Adrenoleukodystrophy

  • Refsum Disease Infantile

  • Peroxisome Biogenesis Disorders

  • Peroxisome Biogenesis Disorder, Type 1b
Rhizomelic Chondrodysplasia Punctata

  • Chondrodysplasia Punctata, Rhizomelic

  • Rcdp

  • Chondrodysplasia Punctata, Rhizomelic Form

  • Rcp

  • Chondrodysplasia Punctata Rhizomelic
Zellweger Syndrome

  • Cerebrohepatorenal Syndrome

  • Zellweger Leukodystrophy

  • Zs

  • Congenital Iron Overload

  • Chr

  • Zws

  • Severe Pbd-Zsd

  • Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10341 PEX11A Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PEX11A RGD RGD:619842
Felis catus PEX11A VGNC VGNC:104575
Macaca mulatta PEX11A VGNC VGNC:75946
Canis familiaris PEX11A VGNC VGNC:44426
Mus musculus PEX11A MGD MGI:1338788
Others PEX11A NCBI