DCAF5 - DDB1 and CUL4 associated factor 5 Gene

Homo sapiens

Also known as BCRG2; BCRP2; WDR22; D14S1461E

Gene ID: 8816 | Gene type: protein coding

About DCAF5

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,050,881-69,153,197 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 20.5), thyroid (RPKM 9.2) and 25 other tissues.

Summary

Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCAF5 Products(4)

mRNA	Protein	Name
NM_001284206.1	NP_001271135.1	DDB1- and CUL4-associated factor 5 isoform 2
NM_001284207.1	NP_001271136.1	DDB1- and CUL4-associated factor 5 isoform 3
NM_001284208.2	NP_001271137.1	DDB1- and CUL4-associated factor 5 isoform 4
NM_003861.3	NP_003852.1	DDB1- and CUL4-associated factor 5 isoform 1

DCAF5 Protein Structure

WD40

0
200
400
600
800
942 a.a.

Protein Preferred Names

Protein Names

DDB1- and CUL4-associated factor 5

WD repeat-containing protein 22

Related Diseases

Diseases

Alias

Leiomyoma

Leiomyomatous Neoplasm	Leiomyomatous Tumor
Leiomyomas	Fibroid Tumor
Uterine Fibroids

Combined Oxidative Phosphorylation Deficiency 30

COXPD30	Combined Oxidative Phosphorylation Defect Type 30
Combined Oxidative Phosphorylation Deficiency, Type 30

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03566	DCAF5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DCAF5	MGD	MGI:2444785
Macaca mulatta	DCAF5	VGNC	VGNC:71683
Rattus norvegicus	DCAF5	RGD	RGD:1306535
Bos taurus	DCAF5	VGNC	VGNC:27905
Felis catus	DCAF5	VGNC	VGNC:61358
Canis familiaris	DCAF5	VGNC	VGNC:39794

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