DCAF5 - DDB1 and CUL4 associated factor 5 Gene

Also Known as BCRG2; BCRP2; WDR22; D14S1461E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8816

About DCAF5

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,050,881-69,153,197 (from NCBI)

This gene has 9 transcripts (splice variants), 207 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 20.5), thyroid (RPKM 9.2) and 25 other tissues.

Summary

Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCAF5 Products (4)

mRNA Protein Name
NM_001284206.1 NP_001271135.1 DDB1- and CUL4-associated factor 5 isoform 2
NM_001284207.1 NP_001271136.1 DDB1- and CUL4-associated factor 5 isoform 3
NM_001284208.2 NP_001271137.1 DDB1- and CUL4-associated factor 5 isoform 4
NM_003861.3 NP_003852.1 DDB1- and CUL4-associated factor 5 isoform 1

DCAF5 Protein Structure

WD40

WD40: WD domain, G-beta repeat (46 - 82)

WD40

WD40: WD domain, G-beta repeat (140 - 171)

WD40

WD40: WD domain, G-beta repeat (283 - 307)

WD40

WD40: WD domain, G-beta repeat (328 - 361)

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  • 942 a.a.
Protein Preferred Names Protein Names

DDB1- and CUL4-associated factor 5

  • WD repeat-containing protein 22

DCAF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DCAF5 Q96JK2 L3MBTL3 Homo sapiens Q96JM7
Anti Bait CoIP
29691401
Intra
DCAF5 Q96JK2 DNMT1 Homo sapiens P26358
Anti Bait CoIP
29691401
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Leiomyoma

  • Leiomyomatous Neoplasm

  • Leiomyomatous Tumor

  • Leiomyomas

  • Fibroid Tumor

  • Uterine Fibroids
Combined Oxidative Phosphorylation Deficiency 30

  • COXPD30

  • Combined Oxidative Phosphorylation Defect Type 30

  • Combined Oxidative Phosphorylation Deficiency, Type 30
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03566 DCAF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DCAF5 MGD MGI:2444785
Macaca mulatta DCAF5 VGNC VGNC:71683
Rattus norvegicus DCAF5 RGD RGD:1306535
Bos taurus DCAF5 VGNC VGNC:27905
Felis catus DCAF5 VGNC VGNC:61358
Canis familiaris DCAF5 VGNC VGNC:39794
Others DCAF5 NCBI