FCHSD1 - FCH and double SH3 domains 1 Gene

Also Known as NWK2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 89848

About FCHSD1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,639,302-141,651,418 (from NCBI)

This gene has 10 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 9.3), lymph node (RPKM 8.7) and 24 other tissues.

Summary

Predicted to enable lipid binding activity. Predicted to be involved in neuromuscular synaptic transmission and positive regulation of actin filament polymerization. Predicted to be located in cell projection and perikaryon. Predicted to be active in neuromuscular junction and recycling endosome. Predicted to colocalize with cuticular plate. [provided by Alliance of Genome Resources, Apr 2022]

FCHSD1 Products (1)

mRNA	Protein	Name
NM_033449.3	NP_258260.1	F-BAR and double SH3 domains protein 1

FCHSD1 Protein Structure

FCH

SH3_9

0
200
400
600
690 a.a.

Protein Preferred Names	Protein Names
F-BAR and double SH3 domains protein 1	FCH and double SH3 domains protein 1

Related Diseases

Diseases	Alias
Large Congenital Melanocytic Nevus	Giant Pigmented Hairy Nevus Giant Congenital Melanocytic Nevus Gmn Congenital Pigmented Nevus Lcmn Gphn Giant Congenital Nevus Bathing Trunk Nevus Congenital Giant Pigmented Nevus Congenital Hairy Nevus Giant Hairy Nevus Giant Pigmented Nevus Congenital Giant Pigmented Nevus Of Skin Congenital Melanocytic Nevus Syndrome Giant Congenital Melanocytic Nevi Giant Congenital Pigmented Nevus Melanocytic Nevus Syndrome, Congenital
Childhood Astrocytic Tumor	Juvenile Astrocytoma Pediatric Astrocytoma
Familial Hypocalciuric Hypercalcemia	Familial Benign Hypercalcemia Fbh Fbhh Fhh Familial Benign Hypocalciuric Hypercalcemia Hypocalciuric Hypercalcemia, Familial, Type 1
Childhood Hepatocellular Carcinoma	Pediatric Hepatocellular Carcinoma Childhood Carcinoma Of Liver Cell Childhood Hepatoma Childhood Liver Cell Carcinoma Pediatric Carcinoma Of Liver Cell Pediatric Hepatoma Pediatric Liver Cell Carcinoma Childhood-Onset Hcc Childhood-Onset Hepatocellular Carcinoma Pediatric Hcc Childhood Liver Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04836	FCHSD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FCHSD1	VGNC	VGNC:108129
Macaca mulatta	FCHSD1	VGNC	VGNC:72574
Mus musculus	FCHSD1	MGD	MGI:2441771
Canis familiaris	FCHSD1	VGNC	VGNC:40806
Felis catus	FCHSD1	VGNC	VGNC:62212
Rattus norvegicus	FCHSD1	RGD	RGD:1308240
Others	FCHSD1	NCBI