FCHSD1 - FCH and double SH3 domains 1 Gene

Homo sapiens

Also known as NWK2

Gene ID: 89848 | Gene type: protein coding

About FCHSD1

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,639,302-141,651,418 (from NCBI)

This gene has 10 transcripts (splice variants), 176 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 9.3), lymph node (RPKM 8.7) and 24 other tissues.

Summary

Predicted to enable lipid binding activity. Predicted to be involved in neuromuscular synaptic transmission and positive regulation of actin filament polymerization. Predicted to be located in cell projection and perikaryon. Predicted to be active in neuromuscular junction and recycling endosome. Predicted to colocalize with cuticular plate. [provided by Alliance of Genome Resources, Apr 2022]

FCHSD1 Products(1)

mRNA	Protein	Name
NM_033449.3	NP_258260.1	F-BAR and double SH3 domains protein 1

FCHSD1 Protein Structure

FCH

SH3_9

0
200
400
600
690 a.a.

Protein Preferred Names

Protein Names

F-BAR and double SH3 domains protein 1

FCH and double SH3 domains protein 1

Related Diseases

Diseases

Alias

Large Congenital Melanocytic Nevus

Giant Pigmented Hairy Nevus	Giant Congenital Melanocytic Nevus
Gmn	Congenital Pigmented Nevus
Lcmn	Gphn
Giant Congenital Nevus	Bathing Trunk Nevus
Congenital Giant Pigmented Nevus	Congenital Hairy Nevus
Giant Hairy Nevus	Giant Pigmented Nevus
Congenital Giant Pigmented Nevus Of Skin	Congenital Melanocytic Nevus Syndrome
Giant Congenital Melanocytic Nevi	Giant Congenital Pigmented Nevus
Melanocytic Nevus Syndrome, Congenital

Childhood Astrocytic Tumor

Juvenile Astrocytoma

Pediatric Astrocytoma

Familial Hypocalciuric Hypercalcemia

Familial Benign Hypercalcemia	Fbh
Fbhh	Fhh
Familial Benign Hypocalciuric Hypercalcemia	Hypocalciuric Hypercalcemia, Familial, Type 1

Childhood Hepatocellular Carcinoma

Pediatric Hepatocellular Carcinoma	Childhood Carcinoma Of Liver Cell
Childhood Hepatoma	Childhood Liver Cell Carcinoma
Pediatric Carcinoma Of Liver Cell	Pediatric Hepatoma
Pediatric Liver Cell Carcinoma	Childhood-Onset Hcc
Childhood-Onset Hepatocellular Carcinoma	Pediatric Hcc
Childhood Liver Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04836	FCHSD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FCHSD1	VGNC	VGNC:108129
Macaca mulatta	FCHSD1	VGNC	VGNC:72574
Mus musculus	FCHSD1	MGD	MGI:2441771
Canis familiaris	FCHSD1	VGNC	VGNC:40806
Felis catus	FCHSD1	VGNC	VGNC:62212
Rattus norvegicus	FCHSD1	RGD	RGD:1308240

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