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SEMA5A - semaphorin 5A Gene

Also Known as semF; SEMAF

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9037

About SEMA5A

Cytogenetic location: 5p15.31 Genomic coordinates (GRCh38): 5:9,035,033-9,546,075 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues, 19 paralogues and is associated with 1 phenotype. Broad expression in lung (RPKM 6.9), kidney (RPKM 6.5) and 24 other tissues.

Summary

This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]

SEMA5A Products (1)

mRNA	Protein	Name
NM_003966.3	NP_003957.2	semaphorin-5A precursor

SEMA5A Protein Structure

Sema

PSI

TSP_1

0
200
400
600
800
1000
1074 a.a.

Protein Preferred Names	Protein Names
semaphorin-5A	sema F

Recombinant SEMA5A Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70496	Semaphorin-5A/SEMA5A Protein, Human (HEK293, His)	Q13591 (E23-T765)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P74560	Semaphorin-5A/SEMA5A Protein, Human (HEK293, Fc)	Q13591 (E23-T765)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Cri-Du-Chat Syndrome	5p Deletion Syndrome 5p Partial Monosomy Syndrome Monosomy 5p Cat Cry Syndrome Chromosome 5p Deletion Syndrome Cri Du Chat Syndrome 5p- Syndrome 5p Minus Syndrome Chromosome 5p- Syndrome Chromosome 5 Short Arm Deletion Syndrome Chromosome 5p Deletion Deletion 5p Cri Du Chat 5p Partial Deletion Syndrome Partial Deletion Of Short Arm Of Chromosome 5 Syndrome
Glioma
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Kallmann Syndrome	Hypogonadism With Anosmia Kallman'S Syndrome Anosmic Hypogonadism Anosmic Idiopathic Hypogonadotropic Hypogonadism Hypogonadotropic Hypogonadism And Anosmia Hypogonadotropic Hypogonadism-Anosmia Syndrome Olfacto-Genital Pathological Sequence Familial Hypogonadism With Anosmia Kallman Syndrome Dysplasia Olfactogenitalis Of De Morsier Kallmann'S Syndrome Congenital Hypogonadotropic Hypogonadism With Anosmia
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12663	SEMA5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19268	Sema5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25757	Sema5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SEMA5A	MGD	MGI:107556
Rattus norvegicus	SEMA5A	RGD	RGD:1308650
Bos taurus	SEMA5A	VGNC	VGNC:34439
Canis familiaris	SEMA5A	VGNC	VGNC:45999
Macaca mulatta	SEMA5A	VGNC	VGNC:77169
Felis catus	SEMA5A	VGNC	VGNC:64997
Others	SEMA5A	NCBI