SLC16A5 - solute carrier family 16 member 5 Gene

Homo sapiens

Also known as MCT5; MCT6

Gene ID: 9121 | Gene type: protein coding

About SLC16A5

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:75,087,385-75,110,149 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues and 13 paralogues. Broad expression in lung (RPKM 9.8), duodenum (RPKM 9.3) and 21 other tissues.

Summary

This gene encodes a member of the Monocarboxylate Transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

SLC16A5 Products(3)

mRNA	Protein	Name
NM_001271765.2	NP_001258694.1	monocarboxylate transporter 6
NM_001369668.1	NP_001356597.1	monocarboxylate transporter 6
NM_004695.4	NP_004686.1	monocarboxylate transporter 6

SLC16A5 Protein Structure

MFS_1

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

monocarboxylate transporter 6

monocarboxylate transporter 5

Related Diseases

Diseases

Alias

Allan-Herndon-Dudley Syndrome

AHDS	Allan-Herndon Syndrome
Monocarboxylate Transporter 8 Deficiency	MCT8 DEFICIENCY
Mental Retardation, X-Linked, With Hypotonia	Triiodothyronine Resistance
T3 Resistance	Mental Retardation And Muscular Atrophy
Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency	Intellectual Disability And Muscular Atrophy
Monocarboxylate Transporter-8 Deficiency	T3 Resisitence
Triiodothyronine Resistence	X-Linked Intellectual Disability With Hypotonia
Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency	Monocarboxylate Transporter 8 Deficiency
X-Linked Intellectual Disability-Hypotonia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13027	SLC16A5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC16A5	MGD	MGI:2443515
Macaca mulatta	SLC16A5	VGNC	VGNC:99257
Rattus norvegicus	SLC16A5	RGD	RGD:1582896
Bos taurus	SLC16A5	VGNC	VGNC:34691
Felis catus	SLC16A5	VGNC	VGNC:65212

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