CENPL - centromere protein L Gene

Also Known as CENP-L; C1orf155; dJ383J4.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 91687

About CENPL

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,799,550-173,824,883 (from NCBI)

This gene has 10 transcripts (splice variants) and 203 orthologues. Broad expression in testis (RPKM 4.2), bone marrow (RPKM 2.4) and 22 other tissues.

Summary

CENPL is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006) [PubMed 16622420].[supplied by OMIM, Mar 2008]

CENPL Products (13)

mRNA Protein Name
NM_001127181.3 NP_001120653.1 centromere protein L isoform 1
NM_001171182.2 NP_001164653.1 centromere protein L isoform 2
NM_001387284.1 NP_001374213.1 centromere protein L isoform 1
NM_001387285.1 NP_001374214.1 centromere protein L isoform 1
NM_001387286.1 NP_001374215.1 centromere protein L isoform 1
NM_001387287.1 NP_001374216.1 centromere protein L isoform 2
NM_001387288.1 NP_001374217.1 centromere protein L isoform 2
NM_001387289.1 NP_001374218.1 centromere protein L isoform 2
NM_001387290.1 NP_001374219.1 centromere protein L isoform 2
NM_001387291.1 NP_001374220.1 centromere protein L isoform 3
NM_001387292.1 NP_001374221.1 centromere protein L isoform 4
NM_001387293.1 NP_001374222.1 centromere protein L isoform 4
NM_033319.4 NP_201576.1 centromere protein L isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence References Source
part of inner kinetochore IPI
IPI: Inferred from physical interaction
36085283 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CENPL Protein Structure

CENP-L

CENP-L: Kinetochore complex Sim4 subunit Fta1 (176 - 325)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

centromere protein L

  • interphase centromere complex protein 33

CENPL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CENPL Q8N0S6 FAM9B Homo sapiens Q8IZU0
Y2H Array
25416956
Intra
CENPL Q8N0S6 FAM9B Homo sapiens Q8IZU0
Y2H Prey Pooling
25416956
Intra
CENPL Q8N0S6 FAM9B Homo sapiens Q8IZU0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Chromosome 17p13.3, Centromeric, Duplication Syndrome

  • Chromosome 17p13.3 Duplication Syndrome

  • 17p13.3 Duplication Syndrome

  • 17p13.3 Microduplication Syndrome

  • Trisomy 17p13.3

  • Chromosome 17p13.3 Centromeric Duplication Syndrome

  • Dup(17)(P13.3)
Villous Adenocarcinoma
Chromosome 22q11.2 Deletion Syndrome, Distal

  • 22q11.2 Deletion Syndrome

  • Autosomal Dominant Opitz G/Bbb Syndrome

  • Catch22

  • Cayler Cardiofacial Syndrome

  • Conotruncal Anomaly Face Syndrome

  • Digeorge Syndrome

  • Sedlackova Syndrome

  • Shprintzen Syndrome

  • Velocardiofacial Syndrome

  • 22q11.2 Distal Deletion Syndrome

  • Distal 22q11.2 Microdeletion Syndrome

  • 22q11.2ds

  • Vcfs

  • Velo-Cardio-Facial Syndrome

  • Distal Chromosome 22q11.2 Deletion Syndrome

  • Chromosome 22q11.2 Deletion Syndrome Distal

  • Chromosome 22q11.2 Deletion Syndrome

  • Deletion 22q11.2 Syndrome

  • 22q11ds

  • Catch 22

  • Digeorge Sequence

  • Microdeletion 22q11.2

  • Monosomy 22q11

  • Takao Syndrome

  • Distal Del(22)(Q11.2)

  • Distal Monosomy 22q11.2

  • Catch 22 Syndrome

  • Chromosome Deletion Syndrome 22q11.2, Distal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02484 CENPL Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CENPL VGNC VGNC:70990
Canis familiaris CENPL VGNC VGNC:39107
Rattus norvegicus CENPL RGD RGD:1311868
Bos taurus CENPL VGNC VGNC:27180
Mus musculus CENPL MGD MGI:1917704
Felis catus CENPL VGNC VGNC:60757
Others CENPL NCBI