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KCNB2 - potassium voltage-gated channel subfamily B member 2 Gene

Also Known as KV2.2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9312

About KCNB2

Cytogenetic location: 8q21.11 Genomic coordinates (GRCh38): 8:72,537,225-72,938,349 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues and 31 paralogues. Low expression observed in reference dataset.

Summary

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, Insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related Potassium Channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the Potassium Channel, voltage-gated, shab-related subfamily. This member is a delayed rectifier Potassium Channel. The gene is expressed in gastrointestinal smooth muscle cells. [provided by RefSeq, Jul 2008]

KCNB2 Products (1)

mRNA	Protein	Name
NM_004770.3	NP_004761.2	potassium voltage-gated channel subfamily B member 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33124732	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNB2 Protein Structure

BTB_2

Ion_trans

Kv2channel

0
200
400
600
800
911 a.a.

Protein Preferred Names	Protein Names
potassium voltage-gated channel subfamily B member 2	delayed rectifier potassium channel protein

Related Diseases

Diseases	Alias
Developmental And Epileptic Encephalopathy 26	DEE26 Epileptic Encephalopathy, Early Infantile, 26 Eiee26 Early Infantile Epileptic Encephalopathy 26 Developmental And Epileptic Encephalopathy, 26 Encephalopathy, Epileptic, Early Infantile, Type 26
Extragonadal Germ Cell Cancer	Extragonadal Germ Cell Tumor Extragonadal Germ Cell Malignant Tumor Neoplasm Of Extragonadal Germ Cell Tumor Of Extragonadal Germ Cell
Spinocerebellar Ataxia 13	Spinocerebellar Ataxia Type 13 SCA13 Autosomal Dominant Cerebellar Ataxia With Intellectual Disability Cerebellar Ataxia, Autosomal Dominant With Intellectual Disability Spinocerebellar Ataxia-13 Ataxia, Spinocerebellar, Type 13
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07107	KCNB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNB2	VGNC	VGNC:67898
Bos taurus	KCNB2	VGNC	VGNC:30431
Macaca mulatta	KCNB2	VGNC	VGNC:73970
Rattus norvegicus	KCNB2	RGD	RGD:621349
Mus musculus	KCNB2	MGD	MGI:99632