MVB12A - multivesicular body subunit 12A Gene

Also Known as CFBP; FAM125A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 93343

Summary

Enables lipid binding activity and ubiquitin binding activity. Involved in regulation of epidermal growth factor receptor signaling pathway. Located in centrosome; cytosol; and vesicle. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Jun 2026]
Ubiquitous expression in ovary (RPKM 33.5), adrenal (RPKM 16.5) and 24 other tissues.

MVB12A Products (2)

mRNA Protein Name
NM_001304547.2 NP_001291476.1 multivesicular body subunit 12A isoform 2
NM_138401.4 NP_612410.1 multivesicular body subunit 12A isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipid binding IMP
IMP: Inferred from mutant phenotype
22232651 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18005716 GOA
enables ubiquitin binding IMP
IMP: Inferred from mutant phenotype
20654576 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20654576 GOA
involved in viral budding IMP
IMP: Inferred from mutant phenotype
18005716 GOA
involved in virus maturation IMP
IMP: Inferred from mutant phenotype
18005716 GOA
Cellular Component GO Annotation Evidence References Source
part of ESCRT I complex IDA
IDA: Inferred from direct assay
18005716 GOA
part of ESCRT I complex IPI
IPI: Inferred from physical interaction
18005716 GOA
located in centrosome IDA
IDA: Inferred from direct assay
18005716 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20654576 GOA
located in vesicle IDA
IDA: Inferred from direct assay
20654576 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MVB12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MVB12A Q96EY5 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
MVB12A Q96EY5 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08855 MVB12B Human Pre-designed siRNA Set A Pre-designed Set / Unkown