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TPTE2 - transmembrane phosphoinositide 3-phosphatase and tensin homolog 2 Gene

Also Known as TPIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 93492

About TPTE2

Cytogenetic location: 13q12.11 Genomic coordinates (GRCh38): 13:19,422,877-19,561,574 (from NCBI)

This gene has 11 transcripts (splice variants), 185 orthologues and 6 paralogues. Restricted expression toward testis (RPKM 4.7).

Summary

TPIP is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositol Phospholipids.[supplied by OMIM, Jul 2002]

TPTE2 Products (5)

mRNA	Protein	Name
NM_001141968.2	NP_001135440.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform delta
NM_001271850.2	NP_001258779.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform C2
NM_001395978.1	NP_001382907.1	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform gamma
NM_130785.4	NP_570141.3	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform alpha
NM_199254.3	NP_954863.2	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 isoform gamma

TPTE2 Protein Structure

Ion_trans

DSPc

PTEN_C2

0
100
200
300
400
522 a.a.

Protein Preferred Names	Protein Names
phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2	PTEN-like inositol lipid phosphatase

TPTE2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810824	TPTE2 Antibody (YA10067)	WB	Human, Mouse

Related Diseases

Diseases	Alias
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14958	TPTE2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25299	Crlf2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TPTE2	MGD	MGI:2446460
Rattus norvegicus	TPTE2	RGD	RGD:1305825
Others	TPTE2	NCBI