KCNK6 - potassium two pore domain channel subfamily K member 6 Gene

Also Known as TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9424

About KCNK6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,319,845-38,332,076 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 14 paralogues. Ubiquitous expression in endometrium (RPKM 7.3), esophagus (RPKM 6.3) and 24 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

KCNK6 Products (1)

mRNA	Protein	Name
NM_004823.3	NP_004814.1	potassium channel subfamily K member 6

KCNK6 Protein Structure

Ion_trans_2

0
100
200
313 a.a.

Protein Preferred Names	Protein Names
potassium channel subfamily K member 6	K2P6.1 potassium channel

Related Diseases

Diseases	Alias
Van Esch-O'Driscoll Syndrome	X-Linked Intellectual Disability, Van Esch Type VEODS Mrxsveod Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Birk-Barel Syndrome	Birk-Barel Mental Retardation Dysmorphism Syndrome BIBARS Mental Retardation With Hypotonia And Facial Dysmorphism Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome Kcnk9 Imprinting Syndrome
Dyskeratosis Congenita, Autosomal Dominant 1	DKCA1 Dyskeratosis Congenita, Scoggins Type Autosomal Dominant Dyskeratosis Congenita 1 Dyskeratosis Congenita, Autosomal Dominant, Type 1 Dyskeratosis Congenita, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07162	KCNK6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	KCNK6	VGNC	VGNC:30476
Canis familiaris	KCNK6	VGNC	VGNC:42278
Rattus norvegicus	KCNK6	RGD	RGD:621450
Mus musculus	KCNK6	MGD	MGI:1891291