2. Gene
  3. KCNK6 - potassium two pore domain channel subfamily K member 6 Gene

KCNK6 - potassium two pore domain channel subfamily K member 6 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TOSS; KCNK8; TWIK2; K2p6.1; TWIK-2

Gene ID: 9424 | Gene type: protein coding

About KCNK6

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:38,319,845-38,332,076 (from NCBI)

This gene has 2 transcripts (splice variants), 204 orthologues and 14 paralogues. Ubiquitous expression in endometrium (RPKM 7.3), esophagus (RPKM 6.3) and 24 other tissues.

Summary

This gene encodes one of the members of the superfamily of Potassium Channel proteins containing two pore-forming P domains. This channel protein, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics. [provided by RefSeq, Jul 2008]

KCNK6 Products(1)

mRNA Protein Name
NM_004823.3 NP_004814.1 potassium channel subfamily K member 6

KCNK6 Protein Structure

Ion_trans_2

Ion_trans_2: Ion channel (89 - 145)

Ion_trans_2

Ion_trans_2: Ion channel (181 - 258)

  • 0
  • 100
  • 200
  • 313 a.a.
Protein Preferred Names Protein Names

potassium channel subfamily K member 6

K2P6.1 potassium channel

Related Diseases

Diseases Alias
Van Esch-O'Driscoll Syndrome

X-Linked Intellectual Disability, Van Esch Type

VEODS

Mrxsveod

Mental Retardation, X-Linked, Syndromic, Van Esch-O'Driscoll Type

X-Linked Syndromic Mental Retardation Van Esch-O'Driscoll Type
Birk-Barel Syndrome

Birk-Barel Mental Retardation Dysmorphism Syndrome

BIBARS

Mental Retardation With Hypotonia And Facial Dysmorphism

Intellectual Disability-Hypotonia-Facial Dysmorphism Syndrome

Kcnk9 Imprinting Syndrome
Dyskeratosis Congenita, Autosomal Dominant 1

DKCA1

Dyskeratosis Congenita, Scoggins Type

Autosomal Dominant Dyskeratosis Congenita 1

Dyskeratosis Congenita, Autosomal Dominant, Type 1

Dyskeratosis Congenita, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07162 KCNK6 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus KCNK6 VGNC VGNC:30476
Canis familiaris KCNK6 VGNC VGNC:42278
Rattus norvegicus KCNK6 RGD RGD:621450
Mus musculus KCNK6 MGD MGI:1891291