ONECUT2 - one cut homeobox 2 Gene

Also Known as OC2; OC-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9480

About ONECUT2

Cytogenetic location: 18q21.31 Genomic coordinates (GRCh38): 18:57,435,374-57,491,298 (from NCBI)

This gene has 2 transcripts (splice variants), 193 orthologues and 2 paralogues. Biased expression in gall bladder (RPKM 4.8), duodenum (RPKM 3.7) and 2 other tissues.

Summary

This gene encodes a member of the onecut family of transcription factors, which are characterized by a cut domain and an atypical homeodomain. The protein binds to specific DNA sequences and stimulates expression of target genes, including genes involved in melanocyte and hepatocyte differentiation. [provided by RefSeq, Jul 2008]

ONECUT2 Products (1)

mRNA Protein Name
NM_004852.3 NP_004843.2 one cut domain family member 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
11478782 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11478782 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11478782 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ONECUT2 Protein Structure

CUT

CUT: CUT domain (328 - 406)

Homeobox

Homeobox: Homeobox domain (427 - 480)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

one cut domain family member 2

  • HNF-6-beta

Related Diseases

Diseases Alias
Ureter, Cancer Of

  • Ureter Carcinoma

  • Ureter Cancer

  • Ureteral Neoplasms

  • Malignant Neoplasm Of Ureter

  • Malignant Tumour Of Ureter

  • Malignant Ureteral Tumor

  • Ureteral Carcinoma

  • Ureteral Neoplasm
Osteogenesis Imperfecta, Type Xvi

  • Osteogenesis Imperfecta Type 16

  • OI16

  • Oi, Type Xvi

  • Osteogenesis Imperfecta Type Xvi

  • Chromosome 11p11.2 Deletion Syndrome 91.3-Kb

  • Osteogenesis Imperfecta 16

  • Chromosome 11p11.2 Deletion Syndrome, 91.3-Kb
Hemophilia B

  • Christmas Disease

  • Factor Ix Deficiency

  • F9 Deficiency

  • HEMB

  • Plasma Thromboplastin Component Deficiency

  • Congenital Factor Ix Deficiency

  • Mild Hemophilia B

  • Severe Hemophilia B

  • Congenital Factor Ix Disorder

  • Deficiency, Functional Factor Ix

  • Hem B

  • Mild Congenital F9 Deficiency

  • Mild Congenital Factor Ix Deficiency

  • Moderate Hemophilia B

  • Moderate Congenital F9 Deficiency

  • Moderate Congenital Factor Ix Deficiency

  • Severe Congenital F9 Deficiency

  • Severe Congenital Factor Ix Deficiency

  • Bleeding Disorder In Hemophilia B Carriers

  • Congenital F9 Deficiency

  • Recessive X-Linked Hemophilia B
Osteogenesis Imperfecta, Type Ii

  • Vrolik Type Of Osteogenesis Imperfecta

  • Osteogenesis Imperfecta Type 2

  • OI2

  • Oi, Type Ii

  • Osteogenesis Imperfecta Congenita

  • Oic

  • Osteogenesis Imperfecta Type Ii

  • Lethal Osteogenesis Imperfecta

  • Oi Type 2

  • Osteogenesis Imperfecta Congenita Perinatal Lethal Form

  • Osteogenesis Imperfecta Congenita, Perinatal Lethal Form

  • Perinatal Lethal Osteogenesis Imperfecta Congenita

  • Perinatally Lethal Oi

  • Osteogenesis Imperfecta 2

  • Oi-Ii

  • Oi-Iia

  • Oi Type Iia

  • Osteogenesis Imperfecta Type Iia

  • Osteogenesis Imperfecta Type Ii Autosomal Dominant

  • Oi Type Ii

  • Osteogenesis Imperfecta, Dominant Perinatal Lethal
Microphthalmia

  • Microphthalmos

  • Isolated Anophthalmia-Microphthalmia Syndrome

  • Isolated Microphthalmia-Anophthalmia-Coloboma

  • Simple Microphthalmos

  • Clinical Anophthalmia

  • Isolated Anophthalmia - Microphthalmia

  • Isolated Pure Microphthalmia

  • Mac Spectrum

  • Microphthalmia-Anophthalmia-Coloboma Spectrum

  • Primitive Anophthalmia

  • Globe Of Eye Small

  • Small Eyeball

  • Hypoplasia Of Eye

  • Isolated Nanophthalmos

  • Rudimentary Eye

  • Dysplasia Of Eye
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122611A CSRM617 hydrochloride 99.97% Unkown
HY-122611 CSRM617 / Unkown
HY-RS09786 ONECUT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19546 Onecut2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26042 Onecut2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ONECUT2 VGNC VGNC:53747
Mus musculus ONECUT2 MGD MGI:1891408
Macaca mulatta ONECUT2 VGNC VGNC:75585
Felis catus ONECUT2 VGNC VGNC:68627
Rattus norvegicus ONECUT2 RGD RGD:1564677
Bos taurus ONECUT2 VGNC VGNC:56369
Others ONECUT2 NCBI