CDC42BPB - CDC42 binding protein kinase beta Gene

Also Known as MRCKB; CHOCNS

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 9578

About CDC42BPB

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,932,380-103,057,549 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 24.8), fat (RPKM 20.9) and 24 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

CDC42BPB Products (2)

mRNA Protein Name
NM_001411054.1 NP_001397983.1 serine/threonine-protein kinase MRCK beta isoform 2
NM_006035.4 NP_006026.3 serine/threonine-protein kinase MRCK beta isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein kinase activity IDA
IDA: Inferred from direct assay
21949762 GOA
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
25743393 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in actomyosin structure organization IMP
IMP: Inferred from mutant phenotype
18854160 GOA
involved in cell migration IMP
IMP: Inferred from mutant phenotype
18854160 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
21949762 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in actomyosin IDA
IDA: Inferred from direct assay
18854160 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42BPB Protein Structure

Pkinase

Pkinase: Protein kinase domain (76 - 341)

DMPK_coil

DMPK_coil: DMPK coiled coil domain like (878 - 939)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (1026 - 1076)

CNH

CNH: CNH domain (1247 - 1509)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1711 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase MRCK beta

  • CDC42 binding protein kinase beta (DMPK-like)

CDC42BPB 抗体

製品番号 製品名 アプリケーション 反応性
HY-P811207 MRCK beta Antibody WB, IHC-P Human, Mouse, Rat

関連疾患

Diseases Alias
Chilton-Okur-Chung Neurodevelopmental Syndrome

  • CHOCNS
Epidermolysis Bullosa Simplex 1a, Generalized Severe

  • Epidermolysis Bullosa Simplex, Dowling-Meara Type

  • Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type

  • EBS1A

  • Ebsdm

  • Epidermolysis Bullosa Simplex Dowling-Meara Type

  • Epidermolysis Bullosa Simplex, Herpetiformis

  • Ebs-Dm

  • Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type

  • Ebs-Gen Sev

  • Epidermolysis Bullosa Herpetiformis Dowling-Meara Type

  • Generalized Severe Epidermolysis Bullosa Simplex

  • Dowling-Meara Type Epidermolysis Bullosa Simplex

  • Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form

  • Autosomal Dominant Generalized Ebs, Severe Form

  • Epidermolysis Bullosa Simplex Herpetiformis

  • Dm-Ebs

  • Epidermolysis Bullosa Simplex, Generalized Severe

  • Epidermolysis Bullosa Herpetiformis, Dowling-Meara

  • Epidermolysis Bullosa Herpetiformis Dowling-Meara
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS02302 CDC42BPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Canis familiaris CDC42BPB VGNC VGNC:38998
Felis catus CDC42BPB VGNC VGNC:60658
Bos taurus CDC42BPB VGNC VGNC:27070
Mus musculus CDC42BPB MGD MGI:2136459
Macaca mulatta CDC42BPB VGNC VGNC:81369
Rattus norvegicus CDC42BPB RGD RGD:621753
Others CDC42BPB NCBI