CDC42BPB - CDC42 binding protein kinase beta Gene

Homo sapiens

Also known as MRCKB; CHOCNS

Gene ID: 9578 | Gene type: protein coding

About CDC42BPB

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,932,380-103,057,549 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 24.8), fat (RPKM 20.9) and 24 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

CDC42BPB Products(2)

mRNA	Protein	Name
NM_001411054.1	NP_001397983.1	serine/threonine-protein kinase MRCK beta isoform 2
NM_006035.4	NP_006026.3	serine/threonine-protein kinase MRCK beta isoform 1

CDC42BPB Protein Structure

Pkinase

DMPK_coil

C1_1

CNH

0
300
600
900
1200
1500
1711 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase MRCK beta

CDC42 binding protein kinase beta (DMPK-like)

Recombinant CDC42BPB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76815	CDC42BPB Protein, Human (sf9, His-GST)	Q9Y5S2 (M1-H427)	≥95%

Related Diseases

Diseases

Alias

Chilton-Okur-Chung Neurodevelopmental Syndrome

CHOCNS

Epidermolysis Bullosa Simplex 1a, Generalized Severe

Epidermolysis Bullosa Simplex, Dowling-Meara Type	Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type
EBS1A	Ebsdm
Epidermolysis Bullosa Simplex Dowling-Meara Type	Epidermolysis Bullosa Simplex, Herpetiformis
Ebs-Dm	Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type
Ebs-Gen Sev	Epidermolysis Bullosa Herpetiformis Dowling-Meara Type
Generalized Severe Epidermolysis Bullosa Simplex	Dowling-Meara Type Epidermolysis Bullosa Simplex
Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form	Autosomal Dominant Generalized Ebs, Severe Form
Epidermolysis Bullosa Simplex Herpetiformis	Dm-Ebs
Epidermolysis Bullosa Simplex, Generalized Severe	Epidermolysis Bullosa Herpetiformis, Dowling-Meara
Epidermolysis Bullosa Herpetiformis Dowling-Meara

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC42BPB	VGNC	VGNC:38998
Felis catus	CDC42BPB	VGNC	VGNC:60658
Bos taurus	CDC42BPB	VGNC	VGNC:27070
Mus musculus	CDC42BPB	MGD	MGI:2136459
Macaca mulatta	CDC42BPB	VGNC	VGNC:81369
Rattus norvegicus	CDC42BPB	RGD	RGD:621753
Others	CDC42BPB	NCBI

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