CDC42BPB - CDC42 binding protein kinase beta Gene

Also Known as MRCKB; CHOCNS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9578

About CDC42BPB

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:102,932,380-103,057,549 (from NCBI)

This gene has 9 transcripts (splice variants), 212 orthologues, 5 paralogues and is associated with 2 phenotypes. Ubiquitous expression in brain (RPKM 24.8), fat (RPKM 20.9) and 24 other tissues.

Summary

This gene encodes a member of the serine/threonine protein kinase family. The encoded protein contains a Cdc42/Rac-binding p21 binding domain resembling that of PAK kinase. The kinase domain of this protein is most closely related to that of myotonic dystrophy kinase-related ROK. Studies of the similar gene in rat suggested that this kinase may act as a downstream effector of Cdc42 in cytoskeletal reorganization. [provided by RefSeq, Jul 2008]

CDC42BPB Products (2)

mRNA	Protein	Name
NM_001411054.1	NP_001397983.1	serine/threonine-protein kinase MRCK beta isoform 2
NM_006035.4	NP_006026.3	serine/threonine-protein kinase MRCK beta isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein kinase activity	IDA IDA: Inferred from direct assay	21949762	GOA
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	25743393	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in actomyosin structure organization	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18854160	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	21949762	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actomyosin	IDA IDA: Inferred from direct assay	18854160	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC42BPB Protein Structure

Pkinase

DMPK_coil

C1_1

CNH

0
300
600
900
1200
1500
1711 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase MRCK beta	CDC42 binding protein kinase beta (DMPK-like)

CDC42BPB Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P811207	MRCK beta Antibody	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Chilton-Okur-Chung Neurodevelopmental Syndrome	CHOCNS
Epidermolysis Bullosa Simplex 1a, Generalized Severe	Epidermolysis Bullosa Simplex, Dowling-Meara Type Epidermolysis Bullosa Herpetiformis, Dowling-Meara Type EBS1A Ebsdm Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex, Herpetiformis Ebs-Dm Epidermolysis Bullosa Simplex 1a, Dowling-Meara Type Ebs-Gen Sev Epidermolysis Bullosa Herpetiformis Dowling-Meara Type Generalized Severe Epidermolysis Bullosa Simplex Dowling-Meara Type Epidermolysis Bullosa Simplex Autosomal Dominant Generalized Epidermolysis Bullosa Simplex, Severe Form Autosomal Dominant Generalized Ebs, Severe Form Epidermolysis Bullosa Simplex Herpetiformis Dm-Ebs Epidermolysis Bullosa Simplex, Generalized Severe Epidermolysis Bullosa Herpetiformis, Dowling-Meara Epidermolysis Bullosa Herpetiformis Dowling-Meara
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02302	CDC42BPB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC42BPB	VGNC	VGNC:38998
Felis catus	CDC42BPB	VGNC	VGNC:60658
Bos taurus	CDC42BPB	VGNC	VGNC:27070
Mus musculus	CDC42BPB	MGD	MGI:2136459
Macaca mulatta	CDC42BPB	VGNC	VGNC:81369
Rattus norvegicus	CDC42BPB	RGD	RGD:621753
Others	CDC42BPB	NCBI