PRDX6 - peroxiredoxin 6 Gene

Homo sapiens

Also known as PRX; p29; AOP2; 1-Cys; NSGPx; aiPLA2; LPCAT-5; HEL-S-128m

Gene ID: 9588 | Gene type: protein coding

About PRDX6

Cytogenetic location: 1q25.1 Genomic coordinates (GRCh38): 1:173,477,335-173,488,815 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 236.1), liver (RPKM 127.7) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional Enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008]

PRDX6 Products(1)

mRNA	Protein	Name
NM_004905.3	NP_004896.1	peroxiredoxin-6

PRDX6 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
200
224 a.a.

Protein Preferred Names

Protein Names

peroxiredoxin-6

1-Cys PRX

Recombinant PRDX6 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71145	PRDX6 Protein, Human (His)	P30041 (M1-P224)	≥95%

Related Diseases

Diseases

Alias

Gnathomiasis

Gnathostomiasis	Infectious Disease By Gnathostoma
Gnathostomosis	Wandering Swelling

Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy	Fuchs Endothelial Dystrophy
Fuchs Dystrophy	Fced
Fuchs' Corneal Dystrophy	Fuchs' Endothelial Corneal Dystrophy
Fuchs Atrophy	Fuchs Corneal Dystrophy
Endoepithelial Corneal Dystrophy	Fecd
Late Hereditary Endothelial Dystrophy	Corneal Dystrophy, Fuchs Endothelial
Dystrophy, Corneal, Fuchs Endothelial	Corneal Dystrophy, Fuchs' Endothelial, 1

Diabetic Cataract

Cataract - Diabetic

Small Intestine Leiomyosarcoma

Leiomyosarcoma Of The Small Bowel	Smooth Muscle Connective Tissue Tumor
Leiomyosarcoma Of Small Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115062	MJ33 lithium salt	Inhibitor	≥99.0%	Unkown
HY-129944A	MJ33-OH lithium	Inhibitor	≥90.0%	Unkown
HY-129944	MJ33-OH	Inhibitor	/	Unkown
HY-RS11079	PRDX6 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PRDX6	VGNC	VGNC:76267
Felis catus	PRDX6	VGNC	VGNC:107925
Bos taurus	PRDX6	VGNC	VGNC:33304
Mus musculus	PRDX6	MGD	MGI:894320
Canis familiaris	PRDX6	VGNC	VGNC:44953
Rattus norvegicus	PRDX6	RGD	RGD:71005
Others	PRDX6	NCBI

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