MRC2 - mannose receptor C type 2 Gene

Also Known as CD280; UPARAP; CLEC13E; ENDO180

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9902

About MRC2

Cytogenetic location: 17q23.2 Genomic coordinates (GRCh38): 17:62,627,670-62,693,597 (from NCBI)

This gene has 7 transcripts (splice variants), 203 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 26.1), ovary (RPKM 24.7) and 24 other tissues.

Summary

This gene encodes a member of the Mannose Receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of Collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast Cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

MRC2 Products (1)

mRNA Protein Name
NM_006039.5 NP_006030.2 C-type mannose receptor 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables collagen binding IDA
IDA: Inferred from direct assay
10636902 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7904248 GOA
Biological Process GO Annotation Evidence References Source
involved in collagen catabolic process IDA
IDA: Inferred from direct assay
12972549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MRC2 Protein Structure

fn2

fn2: Fibronectin type II domain (187 - 228)

Lectin_C

Lectin_C: Lectin C-type domain (256 - 361)

Lectin_C

Lectin_C: Lectin C-type domain (399 - 506)

Lectin_C

Lectin_C: Lectin C-type domain (539 - 645)

Lectin_C

Lectin_C: Lectin C-type domain (694 - 809)

Lectin_C

Lectin_C: Lectin C-type domain (844 - 952)

Lectin_C

Lectin_C: Lectin C-type domain (995 - 1109)

Lectin_C

Lectin_C: Lectin C-type domain (1143 - 1243)

Lectin_C

Lectin_C: Lectin C-type domain (1288 - 1394)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1479 a.a.
Protein Preferred Names Protein Names

C-type mannose receptor 2

  • C-type lectin domain family 13 member E

MRC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
MRC2 Q9UBG0 Col1a1 Rattus norvegicus P02454
SPR
26481812
Cross
MRC2 Q9UBG0 Col1a1 Rattus norvegicus P02454
Solid Phase Assay
26481812
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MRC2 Proteins

Cat. No. Product Name Accession Purity
HY-P700875 MRC2 Protein, Human (HEK293, His) Q9UBG0 (G31-P530) ≥ 95%, as determined by reducing SDS-PAGE.

MRC2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82619 MRC2 Antibody (YA2364) WB Human

Related Diseases

Diseases Alias
Bone Disease

  • Bone Diseases

  • Skeletal Disease

  • Skeletal Disorder

  • Disorder Of Skeletal System
Gliofibroma
Deafness, X-Linked 6

  • DFNX6

  • X-Linked Deafness 6

  • Deafness, X-Linked, 6

  • Deafness, X-Linked, Type 6
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Osteogenesis Imperfecta, Type Iii

  • Osteogenesis Imperfecta Type Iii

  • OI3

  • Oi, Type Iii

  • Osteogenesis Imperfecta Type 3

  • Oi Type Iii

  • Oi Type 3

  • Progressive Deforming Osteogenesis Imperfecta

  • Severe Osteogenesis Imperfecta

  • Osteogenesis Imperfecta, Progressively Deforming, With Normal Sclerae

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclera

  • Osteogenesis Imperfecta, Progressively Deforming With Normal Sclerae

  • Progressively Deforming Oi

  • Osteogenesis Imperfecta 3

  • Oi-Iii

  • Progressively Deforming Osteogenesis Imperfecta With Normal Sclerae
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08642 MRC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19355 Mrc2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25846 Mrc2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris MRC2 VGNC VGNC:43360
Felis catus MRC2 VGNC VGNC:63579
Rattus norvegicus MRC2 RGD RGD:1559436
Mus musculus MRC2 MGD MGI:107818
Bos taurus MRC2 VGNC VGNC:31599
Macaca mulatta MRC2 VGNC VGNC:74784
Others MRC2 NCBI