MRC2 Protein, Human (HEK293, His)

MRC2 Protein potentially acts as an endocytotic lectin receptor with calcium-dependent lectin activity. It internalizes glycosylated ligands through clathrin-mediated endocytosis, releasing them in endosomes. MRC2 may control PLAUR/PLAU levels in the plasminogen activation system, regulating cell surface protease activity. It contributes to cellular uptake, remodeling, and degradation of extracellular collagen matrices, influencing collagen turnover in cancer and tissue destructive diseases. MRC2 collaborates with matrix metalloproteinases, interacting with type I collagen, forming a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly engaging with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics. MRC2 Protein, Human (HEK293, His) is the recombinant human-derived MRC2 protein, expressed by HEK293, with C-His labeled tag. The total length of MRC2 Protein, Human (HEK293, His) is 500 a.a., with molecular weight of 65-75 kDa.

The MRC2 protein is implicated in potentially playing a role as an endocytotic lectin receptor with calcium-dependent lectin activity. It functions by internalizing glycosylated ligands from the extracellular space, releasing them in an endosomal compartment through clathrin-mediated endocytosis. MRC2 may be involved in the plasminogen activation system, controlling the extracellular levels of PLAUR/PLAU and thus regulating protease activity at the cell surface. Additionally, it is suggested to contribute to the cellular uptake, remodeling, and degradation of extracellular collagen matrices, potentially influencing collagen turnover during cancer progression and other chronic tissue destructive diseases. MRC2's involvement in the remodeling of the extracellular matrix is proposed to collaborate with matrix metalloproteinases (MMPs). It interacts with the C-terminal region of type I collagen/COL1A1, forms a tri-molecular complex with PLAUR/UPAR and PLAU/pro-UPA, and directly interacts with collagen V, highlighting its versatile role in cellular processes related to extracellular matrix dynamics.

Human

HEK293

C-His

Q9UBG0 (G31-P530)

9902  [NCBI]

65-75 kDa

Greater than 95% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.