XYLB - xylulokinase Gene

Homo sapiens

Gene ID: 9942 | Gene type: protein coding

About XYLB

Cytogenetic location: 3p22.2 Genomic coordinates (GRCh38): 3:38,346,785-38,453,041 (from NCBI)

This gene has 7 transcripts (splice variants), 196 orthologues and 6 paralogues. Broad expression in liver (RPKM 5.0), kidney (RPKM 3.6) and 18 other tissues.

Summary

The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]

XYLB Products(4)

mRNA	Protein	Name
NM_001349178.2	NP_001336107.1	xylulose kinase isoform 1
NM_001349179.2	NP_001336108.1	xylulose kinase isoform 3
NM_001349180.2	NP_001336109.1	xylulose kinase isoform 4
NM_005108.4	NP_005099.2	xylulose kinase isoform 2

XYLB Protein Structure

FGGY_N

FGGY_C

0
100
200
300
400
500
536 a.a.

Protein Preferred Names

Protein Names

xylulose kinase

D-xylulokinase

Related Diseases

Diseases

Alias

Pentosuria

Xylitol Dehydrogenase Deficiency	L-Xylulosuria
L-Xylulose Reductase Deficiency	Essential Pentosuria
PNTSU	Essential Benign Pentosuria

Terminal Osseous Dysplasia

Terminal Osseous Dysplasia And Pigmentary Defects	Terminal Osseous Dysplasia-Pigmentary Defects Syndrome
Todpd	TOD
Odpd	Odpf Syndrome
Osseous Dysplasia, Digital, With Facial Pigmentary Defects And Multiple Frenula	Odpf
Digital Osseous Dysplasia With Facial Pigmentary Defects And Multiple Frenula	Terminal Osseous Dysplasia With Pigmentary Defects
Dcd	Digitocutaneous Dysplasia
Terminal Osseous Dysplasia And Pigmentary Defect Syndrome	Osseous Dysplasia And Pigmentary Defects

Iminoglycinuria

Iminoglycinuria, Digenic

Neutropenia, Severe Congenital, X-Linked

X-Linked Severe Congenital Neutropenia	XLN
SCNX	Severe Congenital Neutropenia X-Linked
Neutropenia, Congenital, Severe, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15906	XYLB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	XYLB	VGNC	VGNC:78815
Bos taurus	XYLB	VGNC	VGNC:37011
Rattus norvegicus	XYLB	RGD	RGD:1307372
Mus musculus	XYLB	MGD	MGI:2142985
Felis catus	XYLB	VGNC	VGNC:97690
Canis familiaris	XYLB	VGNC	VGNC:48474