Xrcc1 - X-ray repair cross complementing 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84495

Summary

Predicted to enable enzyme binding activity and oxidized DNA binding activity. Predicted to contribute to 3' overhang single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including base-excision repair; response to hypoxia; and response to xenobiotic stimulus. Located in nucleus. Used to study in situ carcinoma. Biomarker of asphyxia neonatorum; transient cerebral ischemia; and visual epilepsy. Human ortholog(s) of this gene implicated in several diseases, including autosomal recessive spinocerebellar ataxia 26; carcinoma (multiple); hematologic Cancer (multiple); hepatitis A; and reproductive organ Cancer (multiple). Orthologous to human XRCC1 (X-ray repair cross complementing 1). [provided by Alliance of Genome Resources, Apr 2022]

Xrcc1 Products (1)

mRNA Protein Name
NM_053435.2 NP_445887.2 DNA repair protein XRCC1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17412650 RGD
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IEP
IEP: Inferred from expression pattern
11056294 RGD
involved in base-excision repair IDA
IDA: Inferred from direct assay
17412650 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
9763211 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11754170 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA repair protein XRCC1

  • X-ray repair complementing defective repair in Chinese hamster cells 1

  • X-ray repair cross-complementing protein 1

  • x-ray repair cross-complementing group 1 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171789 PARG-IN-7 Inhibitor / Unkown
HY-RS15896 XRCC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20130 Xrcc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26634 Xrcc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Xrcc1 NCBI NCBI:7515