1334308-63-2
Chemical Structure
pan-HCN-IN-1
- CAS No.: 1334308-63-2
- Formula:C23H37N3O2
- Molecular Weight:387.56
InChIKey: QQURIRADMQBJKA-UHFFFAOYSA-N
SMILES: CCOC1=CC=CC=C1C(NCC2(CCCCC2)N3CCN(CC3)C(C)C)=O
Biological Activity: pan-HCN-IN-1 is a potent HCN ion channel inhibitor with IC50 values of 58 nM, 522 nM, 58 nM, and 58 nM against HCN1, HCN2, HCN3, and HCN4, respectively. pan-HCN-IN-1 exerts voltage-dependent but not use-dependent inhibition, potently inhibits channels in the closed state, and significantly slows the activation time constant of HCN1 currents. pan-HCN-IN-1 can be used for the research of cognitive dysfunction[1].
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pan-HCN-IN-1 | 99.84% | pan-HCN-IN-1 is a potent HCN ion channel inhibitor with IC50 values of 58 nM, 522 nM, 58 nM, and 58 nM against HCN1, HCN2, HCN3, and HCN4, respectively. pan-HCN-IN-1 exerts voltage-dependent but not use-dependent inhibition, potently inhibits channels in the closed state, and significantly slows the activation time constant of HCN1 currents. pan-HCN-IN-1 can be used for the research of cognitive dysfunction. | ||||||||||||||||||||
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Keywords
