Eif2ak1 - eukaryotic translation initiation factor 2 alpha kinase 1 Gene

Also Known as Hri

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 27137

Summary

Enables eukaryotic translation initiation factor 2alpha kinase activity. Predicted to be involved in several processes, including HRI-mediated signaling; negative regulation of Hemoglobin biosynthetic process; and response to iron ion starvation. Predicted to act upstream of or within several processes, including macrophage differentiation; protoporphyrinogen IX metabolic process; and regulation of cellular macromolecule biosynthetic process. Predicted to be located in cytoplasm. Orthologous to human EIF2AK1 (eukaryotic translation initiation factor 2 alpha kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eif2ak1 Products (1)

mRNA Protein Name
NM_013223.2 NP_037355.2 eukaryotic translation initiation factor 2-alpha kinase 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables eukaryotic translation initiation factor 2alpha kinase activity IDA
IDA: Inferred from direct assay
7908290 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

eukaryotic translation initiation factor 2-alpha kinase 1

  • HCR

  • heme-controlled repressor

  • heme-regulated eukaryotic initiation factor eIF-2-alpha kinase

  • heme-regulated inhibitor

  • hemin-sensitive initiation factor 2-alpha kinase

  • hemin-sensitive initiation factor 2a kinase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147831 HR-19011 99.64% Unkown
HY-RS04242 EIF2AK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04243 EIF2AK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22002 Eif2ak1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28519 Eif2ak1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eif2ak1 NCBI NCBI:27102