GZMA - granzyme A Gene

Also Known as HFSP; CTLA3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3001

About GZMA

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,102,646-55,110,252 (from NCBI)

This gene has 1 transcript (splice variant), 170 orthologues and 5 paralogues. Broad expression in lymph node (RPKM 24.9), spleen (RPKM 21.4) and 20 other tissues.

Summary

Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from Infection by intracellular pathogens. The protein described here is a T cell- and natural killer cell-specific serine protease that may function as a common component necessary for lysis of target cells by cytotoxic T lymphocytes and natural killer cells. [provided by RefSeq, Jul 2008]

GZMA Products (1)

mRNA	Protein	Name
NM_006144.4	NP_006135.2	granzyme A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12524539	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12819770	GOA
enables serine-type endopeptidase activity	IDA IDA: Inferred from direct assay	11331782	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cytotoxic T cell pyroptotic cell death	IDA IDA: Inferred from direct assay	32299851	GOA
involved in granzyme-mediated programmed cell death signaling pathway	IDA IDA: Inferred from direct assay	32299851	GOA
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	12524539	GOA
involved in negative regulation of endodeoxyribonuclease activity	IDA IDA: Inferred from direct assay	12524539	GOA
involved in negative regulation of oxidoreductase activity	IDA IDA: Inferred from direct assay	12524539	GOA
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	12524539	GOA
involved in protein maturation	IDA IDA: Inferred from direct assay	32299851	GOA
involved in proteolysis involved in protein catabolic process	IDA IDA: Inferred from direct assay	12524539	GOA
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	32299851	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in cytoplasm	IDA IDA: Inferred from direct assay	20038786	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GZMA Protein Structure

Trypsin

0
100
200
262 a.a.

Protein Preferred Names	Protein Names
granzyme A	CTL tryptase

Recombinant GZMA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76377	GZMA/Granzyme A Protein, Human (HEK293, His)	P12544-1/NP_006135.1 (E27-V262)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Chediak-Higashi Syndrome	CHS Chédiak-Higashi Syndrome Chediak - Steinbrinck Anomaly Chediak Higashi Syndrome Chediak-Steinbrinck-Higashi Syndrome Oculocutaneous Albinism With Leukocyte Defect Chediak-Higashi Disease Chediak-Higashi-Steinbrink Syndrome
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Ankylosing Spondylitis 3
Shigellosis	Dysentery, Bacillary Bacillary Dysentery Shigella Boydii Infectious Disease Shigella Flexneri Infectious Disease Shigella Gastroenteritis Shigella Sonnei Infectious Disease Shigella Infections
Human Immunodeficiency Virus Infectious Disease	Hiv Infections
Viral Infectious Disease	Viral Disease Arbovirus Infections Virus Infection Virus Diseases Viral Infection Viral Infections Virus Infections

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05939	GZMA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17164	Gzma Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23614	Gzma Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GZMA	VGNC	VGNC:67526
Rattus norvegicus	GZMA	RGD	RGD:628640
Canis familiaris	GZMA	VGNC	VGNC:41577
Macaca mulatta	GZMA	VGNC	VGNC:73336
Mus musculus	GZMA	MGD	MGI:109266
Others	GZMA	NCBI