OSBP2 - oxysterol binding protein 2 Gene

Also Known as HLM; ORP4; ORP-4; OSBPL1; OSBPL4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23762

About OSBP2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,693,782-30,907,813 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 11 paralogues. Broad expression in bone marrow (RPKM 10.4), testis (RPKM 8.8) and 17 other tissues.

Summary

The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

OSBP2 Products (6)

mRNA Protein Name
NM_001282738.2 NP_001269667.1 oxysterol-binding protein 2 isoform c
NM_001282739.2 NP_001269668.1 oxysterol-binding protein 2 isoform d
NM_001282740.2 NP_001269669.1 oxysterol-binding protein 2 isoform e
NM_001282741.2 NP_001269670.1 oxysterol-binding protein 2 isoform f
NM_001282742.2 NP_001269671.1 oxysterol-binding protein 2 isoform g
NM_030758.4 NP_110385.1 oxysterol-binding protein 2 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cholesterol binding IDA
IDA: Inferred from direct assay
17428193 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSBP2 Protein Structure

PH

PH: PH domain (186 - 271)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (522 - 902)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 916 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein 2

  • OSBP-related protein 4

OSBP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
OSBP2 Q969R2 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
OSBP2 Q969R2 LNX1 Homo sapiens Q8TBB1
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Opisthorchiasis

  • Infection By Opisthorchis

  • Infection Due To Opisthorchis

  • Infection Due To Cat Liver Fluke

  • Infection By Cat Liver Fluke

  • Opisthorchiosis

  • Cat Liver Fluke Fever

  • Cat Liver Fluke Disease

  • Opisthorchis Infestation

  • Cat Liver Fluke Infestation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09836 OSBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OSBP2 MGD MGI:1921559
Macaca mulatta OSBP2 VGNC VGNC:75719
Rattus norvegicus OSBP2 RGD RGD:1310505
Bos taurus OSBP2 VGNC VGNC:32457
Felis catus OSBP2 VGNC VGNC:68657
Canis familiaris OSBP2 VGNC VGNC:44150
Others OSBP2 NCBI