2. Gene
  3. OSBP2 - oxysterol binding protein 2 Gene

OSBP2 - oxysterol binding protein 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HLM; ORP4; ORP-4; OSBPL1; OSBPL4

Gene ID: 23762 | Gene type: protein coding

About OSBP2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,693,782-30,907,813 (from NCBI)

This gene has 19 transcripts (splice variants), 205 orthologues and 11 paralogues. Broad expression in bone marrow (RPKM 10.4), testis (RPKM 8.8) and 17 other tissues.

Summary

The protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2013]

OSBP2 Products(6)

mRNA Protein Name
NM_001282738.2 NP_001269667.1 oxysterol-binding protein 2 isoform c
NM_001282739.2 NP_001269668.1 oxysterol-binding protein 2 isoform d
NM_001282740.2 NP_001269669.1 oxysterol-binding protein 2 isoform e
NM_001282741.2 NP_001269670.1 oxysterol-binding protein 2 isoform f
NM_001282742.2 NP_001269671.1 oxysterol-binding protein 2 isoform g
NM_030758.4 NP_110385.1 oxysterol-binding protein 2 isoform a

OSBP2 Protein Structure

PH

PH: PH domain (186 - 271)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (522 - 902)

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  • 916 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein 2

OSBP-related protein 4

Related Diseases

Diseases Alias
Opisthorchiasis

Infection By Opisthorchis

Infection Due To Opisthorchis

Infection Due To Cat Liver Fluke

Infection By Cat Liver Fluke

Opisthorchiosis

Cat Liver Fluke Fever

Cat Liver Fluke Disease

Opisthorchis Infestation

Cat Liver Fluke Infestation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09836 OSBP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus OSBP2 MGD MGI:1921559
Macaca mulatta OSBP2 VGNC VGNC:75719
Rattus norvegicus OSBP2 RGD RGD:1310505
Bos taurus OSBP2 VGNC VGNC:32457
Felis catus OSBP2 VGNC VGNC:68657
Canis familiaris OSBP2 VGNC VGNC:44150