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Lep - leptin Gene

Also Known as OB; obese

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25608

Summary

Enables hormone activity and peptide hormone receptor binding activity. Involved in several processes, including positive regulation of cell communication; regulation of apoptotic process; and response to vitamin. Located in cytosol and extracellular space. Used to study several diseases, including alcohol dependence; glucose metabolism disease (multiple); liver disease (multiple); neurodegenerative disease (multiple); and short bowel syndrome. Biomarker of several diseases, including Huntington's disease; alcohol dependence; fatty liver disease (multiple); lipid metabolism disorder (multiple); and obesity. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; congenital Leptin deficiency; fatty liver disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human LEP (Leptin). [provided by Alliance of Genome Resources, Apr 2022]

Lep Products (1)

mRNA	Protein	Name
NM_013076.3	NP_037208.1	leptin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hormone activity	IDA IDA: Inferred from direct assay	9070213	RGD
enables peptide hormone receptor binding	IDA IDA: Inferred from direct assay	9070213	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	17324488	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	15131016	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in bone mineralization involved in bone maturation	IDA IDA: Inferred from direct assay	21353474	RGD
involved in cardiac muscle hypertrophy	IDA IDA: Inferred from direct assay	20738325	RGD
involved in cellular response to L-ascorbic acid	IEP IEP: Inferred from expression pattern	20400526	RGD
involved in cellular response to retinoic acid	IEP IEP: Inferred from expression pattern	19212007	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	21164040	RGD
involved in energy reserve metabolic process	IDA IDA: Inferred from direct assay	12058043	RGD
involved in fatty acid catabolic process	IDA IDA: Inferred from direct assay	12058043	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	21303957	RGD
involved in glycerol biosynthetic process	IDA IDA: Inferred from direct assay	21068181	RGD
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	12130569	RGD
involved in leptin-mediated signaling pathway	IDA IDA: Inferred from direct assay	9070213	RGD
involved in leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	20150963	RGD
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19730157	RGD
involved in negative regulation of appetite by leptin-mediated signaling pathway	IDA IDA: Inferred from direct assay	11677594	RGD
involved in negative regulation of cartilage development	IDA IDA: Inferred from direct assay	19876764	RGD
involved in negative regulation of glutamine transport	IMP IMP: Inferred from mutant phenotype	20448142	RGD
involved in negative regulation of lipid storage	IDA IDA: Inferred from direct assay	17024416	RGD
involved in negative regulation of metabolic process	IDA IDA: Inferred from direct assay	12130569	RGD
involved in negative regulation of vasoconstriction	IDA IDA: Inferred from direct assay	20978518	RGD
involved in ovulation from ovarian follicle	IDA IDA: Inferred from direct assay	17071778	RGD
involved in phagocytosis	IDA IDA: Inferred from direct assay	9438411	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	9618284	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	18978578	RGD
involved in positive regulation of cytokine production	IEP IEP: Inferred from expression pattern	19922787	RGD
involved in positive regulation of fat cell apoptotic process	IDA IDA: Inferred from direct assay	17024416	RGD
involved in positive regulation of follicle-stimulating hormone secretion	IEP IEP: Inferred from expression pattern	19112389	RGD
involved in positive regulation of hepatic stellate cell activation	IDA IDA: Inferred from direct assay	19299451	RGD
involved in positive regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	20977462	RGD
involved in positive regulation of luteinizing hormone secretion	IEP IEP: Inferred from expression pattern	19112389	RGD
involved in positive regulation of monoatomic ion transport	IDA IDA: Inferred from direct assay	20203064	RGD
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	20738325	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	11677594	RGD
involved in positive regulation of protein modification process	IMP IMP: Inferred from mutant phenotype	19726711	RGD
involved in positive regulation of reactive oxygen species metabolic process	IDA IDA: Inferred from direct assay	20738325	RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT	IMP IMP: Inferred from mutant phenotype	21250909	RGD
involved in regulation of blood pressure	IDA IDA: Inferred from direct assay	20059648	RGD
involved in regulation of lipoprotein lipid oxidation	IDA IDA: Inferred from direct assay	21068181	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	23178146	RGD
involved in response to dietary excess	IMP IMP: Inferred from mutant phenotype	19726711	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	12412816	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	23380443	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	15284063	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15616803	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	21060836	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	20404018	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	17324488	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	9590691	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
leptin	obesity factor

Recombinant Lep Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7233	Leptin Protein, Rat	P50596 (V22-C167)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P7233A	Leptin Protein, Rat (His)	P50596 (V22-C167)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07593	LEP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17798	Lep Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24266	Lep Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lep	NCBI	NCBI:3952