ATP5PB - ATP synthase peripheral stalk-membrane subunit b Gene

Also Known as PIG47; ATP5F1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 515

About ATP5PB

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,449,464-111,462,773 (from NCBI)

This gene has 6 transcripts (splice variants) and 266 orthologues. Ubiquitous expression in heart (RPKM 107.3), colon (RPKM 76.0) and 25 other tissues.

Summary

This gene encodes a subunit of mitochondrial ATP Synthase. Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. ATP Synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP Synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the Other 3. The proton channel seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the b subunit of the proton channel. [provided by RefSeq, Jul 2008]

ATP5PB Products (1)

mRNA Protein Name
NM_001688.5 NP_001679.2 ATP synthase F(0) complex subunit B1, mitochondrial precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19016746 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence References Source
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence References Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATP5PB Protein Structure

Mt_ATP-synt_B

Mt_ATP-synt_B: Mitochondrial ATP synthase B chain precursor (ATP-synt_B) (83 - 244)

  • 0
  • 100
  • 200
  • 256 a.a.
Protein Preferred Names Protein Names

ATP synthase F(0) complex subunit B1, mitochondrial

  • ATP synthase B chain, mitochondrial

ATP5PB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ATP5PB P24539 DELE1 Homo sapiens Q14154
Y2H Pooling
32814053
Intra
ATP5PB P24539 DELE1 Homo sapiens Q14154
Validated Y2H
32814053
Intra
ATP5PB P24539 DELE1 Homo sapiens Q14154
Y2H Array
32814053
Intra
ATP5PB P24539 ATP5F1A Homo sapiens P25705
BN-PAGE
19688755
Intra
ATP5PB P24539 ATP5F1A Homo sapiens P25705
Anti Tag CoIP
33961781
Intra
ATP5PB P24539 ATP5F1A Homo sapiens P25705
Anti Tag CoIP
28514442
Intra
ATP5PB P24539 ATP5F1A Homo sapiens P25705
Crosslink
30021884
Intra
ATP5PB P24539 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
ATP5PB P24539 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
ATP5PB P24539 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
ATP5PB P24539 ATP5PD Homo sapiens O75947
Anti Tag CoIP
33961781
Intra
ATP5PB P24539 ATP5PD Homo sapiens O75947
BN-PAGE
19688755
Intra
ATP5PB P24539 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32814053
Intra
ATP5PB P24539 METTL27 Homo sapiens Q8N6F8
Y2H Array
32814053
Intra
ATP5PB P24539 METTL27 Homo sapiens Q8N6F8
Y2H Pooling
32814053
Intra
ATP5PB P24539 ATXN1 Homo sapiens P54253
Y2H Pooling
32814053
Intra
ATP5PB P24539 ATXN1 Homo sapiens P54253
Validated Y2H
32814053
Intra
ATP5PB P24539 ATXN1 Homo sapiens P54253
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

ATP5PB Antibodies

Cat. No. Product Name Application Reactivity
HY-P86778 ATP5F1 Antibody (YA6471) WB, ICC/IF, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01211 ATP5PB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ATP5PB MGD MGI:1100495
Bos taurus ATP5PB VGNC VGNC:26303
Rattus norvegicus ATP5PB RGD RGD:620041
Felis catus ATP5PB VGNC VGNC:80146
Others ATP5PB NCBI