PRKAB1 - protein kinase AMP-activated non-catalytic subunit beta 1 Gene

Also Known as AMPK; HAMPKb

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5564

About PRKAB1

Cytogenetic location: 12q24.23 Genomic coordinates (GRCh38): 12:119,667,952-119,681,619 (from NCBI)

This gene has 10 transcripts (splice variants), 285 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 25.5), bone marrow (RPKM 15.9) and 25 other tissues.

Summary

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key Enzymes involved in regulating de novo biosynthesis of fatty acid and Cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex. [provided by RefSeq, Jul 2008]

PRKAB1 Products (1)

mRNA Protein Name
NM_006253.5 NP_006244.2 5'-AMP-activated protein kinase subunit beta-1

PRKAB1 Protein Structure

AMPKBI

AMPKBI: 5'-AMP-activated protein kinase beta subunit, interaction domain (191 - 270)

  • 0
  • 100
  • 200
  • 270 a.a.
Protein Preferred Names Protein Names

5'-AMP-activated protein kinase subunit beta-1

  • 5'-AMP-activated protein kinase beta-1 subunit

PRKAB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRKAB1 Q9Y478 PRKAA1 Homo sapiens Q13131
Anti Tag CoIP
33961781
Intra
PRKAB1 Q9Y478 PRKAA1 Homo sapiens Q13131
Anti Tag CoIP
20562859
Intra
PRKAB1 Q9Y478 PRKAA1 Homo sapiens Q13131
Anti Bait CoIP
22363791
Intra
PRKAB1 Q9Y478 PRKAG1 Homo sapiens P54619
Y2H Array
21988832
Intra
PRKAB1 Q9Y478 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
20562859
Intra
PRKAB1 Q9Y478 PRKAG1 Homo sapiens P54619
Anti Tag CoIP
33961781
Intra
PRKAB1 Q9Y478 PRKAG1 Homo sapiens P54619
Anti Bait CoIP
22363791
Intra
PRKAB1 Q9Y478 PRKAA2 Homo sapiens P54646
Anti Tag CoIP
20562859
Intra
PRKAB1 Q9Y478 PRKAA2 Homo sapiens P54646
Anti Tag CoIP
33961781
Intra
PRKAB1 Q9Y478 PRKAA2 Homo sapiens P54646
Anti Tag CoIP
28514442
Intra
PRKAB1 Q9Y478 GRB2 Homo sapiens P62993
Y2H
18624398
Intra
PRKAB1 Q9Y478 GRB2 Homo sapiens P62993
Anti Tag CoIP
18624398
Cross
PRKAB1 Q9Y478 Cidea Mus musculus O70302
Anti Tag CoIP
18480843
Cross
PRKAB1 Q9Y478 Cidea Mus musculus O70302
Anti Bait CoIP
18480843
Cross
PRKAB1 Q9Y478 Cidea Mus musculus O70302
IF
18480843
Intra
PRKAB1 Q9Y478 ULK1 Homo sapiens O75385
Anti Tag CoIP
21072212
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRKAB1 Proteins

Cat. No. Product Name Accession Purity
HY-P76141 AMPK gamma 1/beta 1/alpha 1 Heterotrimer Protein, Human (Active, sf9, His-GST) P54619-1 (M1-P331)&Q9Y478 (M1-I270)&Q13131-1 (M1-Q559) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P76142 AMPK gamma 1/beta 1/alpha 2 Heterotrimer Protein, Human (Active, sf9, His-GST) P54619-1 (M1-P331)&Q9Y478 (M1-I270)&P54646 (M1-R552) ≥ 90%, as determined by reducing SDS-PAGE.

PRKAB1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80542 AMPK beta 1 Antibody WB, IHC-P, FC, IP Human, Mouse, Rat
HY-P85578 AMPK beta 1 Antibody (YA5270) WB, ICC/IF, IP, IHC-P Human, Mouse, Rat, Monkey
HY-P85708 AMPK beta 1 Antibody (YA5400) IHC-P, WB Human, Mouse, Rat

Related Diseases

Diseases Alias
Krabbe Disease

  • Globoid Cell Leukodystrophy

  • Galactosylceramide Beta-Galactosidase Deficiency

  • Galc Deficiency

  • Galactocerebrosidase Deficiency

  • GLD

  • Globoid Cell Leukoencephalopathy

  • Diffuse Globoid Body Sclerosis

  • Gcl

  • Leukodystrophy, Globoid Cell

  • Krabbe'S Leukodystrophy

  • Krabbe Leukodystrophy

  • KRB

  • Beta Galactocerebrosidase Deficiency

  • Krabbe'S Disease

  • Galactosylceramidase Deficiency Disease

  • Galactosylceramide Lipidosis

  • Galactosylcerebrosidase Deficiency

  • Galactosylsphingosine Lipidosis

  • Psychosine Lipidosis

  • Galactosylceramidase Deficiency

  • Infantile Globoid Cell Leukodystrophy

  • Krabbe Brain Sclerosis
Hyperglycemia
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Kidney Cancer

  • Renal Cancer

  • Renal Carcinoma

  • Kidney Neoplasm

  • Malignant Neoplasm Of Kidney Except Pelvis

  • Malignant Tumour Of Kidney

  • Kidney Neoplasms

  • Cancer, Kidney

  • Cancer, Renal

  • Malignant Neoplasm Of Kidney

  • Renal Cell Carcinoma
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11102 PRKAB1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PRKAB1 VGNC VGNC:44969
Mus musculus PRKAB1 MGD MGI:1336167
Bos taurus PRKAB1 VGNC VGNC:33319
Rattus norvegicus PRKAB1 RGD RGD:71057
Macaca mulatta PRKAB1 VGNC VGNC:76401
Felis catus PRKAB1 VGNC VGNC:69047
Others PRKAB1 NCBI