Cidea - cell death-inducing DNA fragmentation factor, alpha subunit-like effector A Gene

Species: Mus musculus

Gene Type: protein coding

Gene ID: 12683

Summary

Enables protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; negative regulation of transforming growth factor beta receptor signaling pathway; and positive regulation of sequestering of triglyceride. Acts upstream of or within lipid metabolic process and response to stilbenoid. Located in mitochondrial envelope and nucleus. Colocalizes with lipid droplet. Is expressed in brown fat. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a). [provided by Alliance of Genome Resources, Apr 2022]

Cidea Products (1)

mRNA	Protein	Name
NM_007702.2	NP_031728.2	cell death activator CIDE-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables lipid transfer activity	IDA IDA: Inferred from direct assay	22144693	MGI
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	26609809	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12910269	MGI
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	17080483	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to cold	IDA IDA: Inferred from direct assay	28763438	MGI
involved in lipid droplet fusion	IDA IDA: Inferred from direct assay	22144693	MGI
acts upstream of or within lipid metabolic process	IMP IMP: Inferred from mutant phenotype	12910269	MGI
involved in lipid storage	IDA IDA: Inferred from direct assay	22144693	MGI
involved in lipid storage	IMP IMP: Inferred from mutant phenotype	12910269	MGI
involved in negative regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	12910269	MGI
involved in negative regulation of execution phase of apoptosis	IDA IDA: Inferred from direct assay	17080483	MGI
involved in negative regulation of lipid catabolic process	IMP IMP: Inferred from mutant phenotype	12910269	MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	17080483	MGI
involved in positive regulation of sequestering of triglyceride	IDA IDA: Inferred from direct assay	18509062	MGI
involved in regulation of apoptotic DNA fragmentation	IDA IDA: Inferred from direct assay	9564035	MGI
involved in response to stilbenoid	IEP IEP: Inferred from expression pattern	17086191	MGI
involved in temperature homeostasis	IMP IMP: Inferred from mutant phenotype	12910269	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17080483	MGI
colocalizes with lipid droplet	IDA IDA: Inferred from direct assay	18509062	MGI
is active in lipid droplet	IDA IDA: Inferred from direct assay	20810722	MGI
located in mitochondrial envelope	IDA IDA: Inferred from direct assay	12910269	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	12910269	MGI
located in nucleus	IDA IDA: Inferred from direct assay	17080483	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
cell death activator CIDE-A	cell death-inducing DFFA-like effector A

Cidea Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Cidea	O70302	PRKAB1	Homo sapiens	Q9Y478	IF	18480843

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N9933	Tauro-β-muricholic acid		99.91%	Unkown
HY-Y0598	trans-Chalcone		99.25%	Unkown
HY-183094	AM73		/	Unkown
HY-183095	AM79		/	Unkown
HY-183096	AM31		/	Unkown
HY-RS02711	CIDEA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19419	Cidea Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25910	Cidea Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cidea	NCBI	NCBI:1149