AM79 

AM79 is a PGC-1α1 stabilizer. AM79 promotes the accumulation of endogenous PGC-1α1 protein, thereby activating its target genes. AM79 increases uncoupled mitochondrial respiration in brown adipocytes. AM79 induces the expression of Ucp1 and Cidea in brown adipocytes. AM79 can be used for the research of obesity and related metabolic disorders^[1].

AM79 (10 μM; 8 h) enhances the fluorescence intensity of EGFP-PGC-1α1 in HEK 293-EGFPmPGC-1α1 cells, indicating stabilization of the PGC-1α1 fusion protein, with an activation rate of 57.1% relative to proteasome inhibition^[1].
AM79 (10 μM; 8 h) significantly induces the expression of thermogenic and mitochondrial target genes (including the upregulated expression of *Ucp1*) in fully differentiated immortalized mouse brown adipocytes, without altering the total expression level of the *PGC-1α* gene^[1].
AM79 (10 μM; 8 h) stabilizes endogenous PGC-1α protein in fully differentiated immortalized mouse brown adipocytes^[1].
AM79 (10 μM; 8 h) increases basal mitochondrial respiration and uncoupled mitochondrial respiration (12% increase in proton leak) in fully differentiated immortalized mouse brown adipocytes, with no effect on maximal respiratory capacity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

412.48

C₂₅H₂₄N₄O₂

949229-08-7

O=C(C(CC1)=NN(C2=CC(C)=CC=C2)C1=O)N(CC3)CC=C3C4=CNC5=C4C=CC=C5

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Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pettersson-Klein AT, et al. Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration. Mol Metab. 2018;9:28-42.