GEMIN7 - gem nuclear organelle associated protein 7 Gene

Also Known as SIP3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79760

About GEMIN7

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,075,627-45,091,518 (from NCBI)

This gene has 5 transcripts (splice variants) and 178 orthologues. Ubiquitous expression in lymph node (RPKM 4.5), spleen (RPKM 4.2) and 25 other tissues.

Summary

The protein encoded by this gene is a component of the core SMN complex, which is required for pre-mRNA splicing in the nucleus. The encoded protein is found in the nucleoplasm, in nuclear "gems" (Gemini of Cajal bodies), and in the cytoplasm. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

GEMIN7 Products (5)

mRNA Protein Name
NM_001007269.2 NP_001007270.1 gem-associated protein 7
NM_001007270.2 NP_001007271.1 gem-associated protein 7
NM_001319054.1 NP_001305983.1 gem-associated protein 7
NM_001319055.2 NP_001305984.1 gem-associated protein 7
NM_024707.3 NP_078983.1 gem-associated protein 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12065586 GOA
Biological Process GO Annotation Evidence References Source
involved in spliceosomal snRNP assembly EXP
EXP: Inferred from Experiment
12067652 GOA
involved in spliceosomal snRNP assembly IDA
IDA: Inferred from direct assay
18984161 GOA
Cellular Component GO Annotation Evidence References Source
located in Gemini of coiled bodies IDA
IDA: Inferred from direct assay
20513430 GOA
part of SMN complex IDA
IDA: Inferred from direct assay
17178713 GOA
part of SMN complex IPI
IPI: Inferred from physical interaction
17178713 GOA
part of SMN-Sm protein complex IDA
IDA: Inferred from direct assay
18984161 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
12065586 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
located in nuclear body IDA
IDA: Inferred from direct assay
12065586 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
12065586 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GEMIN7 Protein Structure

Gemin7

Gemin7: Gem-associated protein 7 (Gemin7) (52 - 130)

  • 0
  • 100
  • 131 a.a.
Protein Preferred Names Protein Names

gem-associated protein 7

  • gemin-7

GEMIN7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GEMIN7 Q9H840 STRAP Homo sapiens Q9Y3F4
Anti Tag CoIP
33961781
Intra
GEMIN7 Q9H840 STRAP Homo sapiens Q9Y3F4
Pull Down
15848170
Intra
GEMIN7 Q9H840 STRAP Homo sapiens Q9Y3F4
Anti Tag CoIP
26496610
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Array
31515488
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Prey Pooling
25416956
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Validated Y2H
25416956
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Prey Pooling
32296183
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Anti Tag CoIP
26496610
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Array
25416956
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Anti Tag CoIP
33961781
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Array
32296183
Intra
GEMIN7 Q9H840 GEMIN6 Homo sapiens Q8WXD5
Y2H Pooling
16189514
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebellar Ataxia Type 9

  • Sca9
Childhood Spinal Muscular Atrophy

  • Spinal Muscular Atrophies Of Childhood

  • Survival Motor Neuron Spinal Muscular Atrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05370 GEMIN7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GEMIN7 VGNC VGNC:29320
Canis familiaris GEMIN7 VGNC VGNC:41177
Mus musculus GEMIN7 MGD MGI:1916981
Rattus norvegicus GEMIN7 RGD RGD:1597035
Others GEMIN7 NCBI