Garlic oil blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung tumorigenesis by inducing phase II drug-metabolizing enzymes

  • Food Chem Toxicol. 2021 Nov:157:112581. doi: 10.1016/j.fct.2021.112581.
Lei Zhang  1 ,  Zhuo Qu  1 ,  Aiwei Song  2 ,  Jianhong Yang  1 ,  Jianqiang Yu  1 ,  Wannian Zhang  3 ,  Chunlin Zhuang  4
Affiliations
  • 1. School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China.
  • 2. Montverde Academy Shanghai, 508 South Hanqing Road, Shanghai, 201201, China.
  • 3. School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. Electronic address: [email protected].
  • 4. School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan, 750004, China; School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai, 200433, China. Electronic address: [email protected].
PMID: 34562529 DOI: 10.1016/j.fct.2021.112581
Abstract

Lung Cancer caused one-quarter of all Cancer deaths that was more than Other cancers. Chemoprevention is a potential strategy to reducing lung Cancer incidence and death, and the effective chemopreventive agents are needed. We investigated the efficacy and mechanism of garlic oil (GO), the garlic product, in the chemoprevention of tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)-induced lung Cancer in A/J mice and MRC-5 cell models in the present study. As a result, it was demonstrated that GO significantly inhibited the NNK-induced lung Cancer in vivo and protected MRC-5 cells from NNK-induced cell damage. GO could induce the expressions of the phase II drug-metabolizing Enzymes, including NAD(P)H: quinone oxidoreductase 1 (NQO-1), Glutathione S-transferase alpha 1 (GSTA1), and antioxidative Enzymes heme oxygenase-1 (HO-1). These results supported the potential of GO as a novel candidate agent for the chemoprevention of tobacco carcinogens induced lung Cancer.

Keywords
Chemoprevention; Garlic oil; Lung cancer; NNK; Phase II drug-Metabolizing enzymes.
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