Antibacterial agent 237

Antibacterial agent 237 has antibacterial effects on S. aureus Newman, S. aureus ATCC 29213, Methicillin-resistant S. aureus ATCC 33591, E. coli 25922, and PAO1, with MICs of 0.78 μg/mL, 1.56 μg/mL, 1.56 μg/mL, 100 μg/mL, and 50 μg/mL^[1].
Antibacterial agent 237 still maintains the activity of inhibiting S. aureus Newman at high salt concentrations, with a MIC of 0.78 μg/mL, and remains stable in mammalian body fluids (serum, plasma and blood) ^[1].
Antibacterial agent 237 (0-4.68 μg/mL, 0-120 min) can kill S. aureus Newman efficiently and quickly, and is concentration-dependent, effectively avoiding the development of drug resistance^[1].
Antibacterial agent 237 (0-49.92 μg/mL, 24 h) can remove S. aureus Newman biofilms in a dose-dependent manner^[1].
Antibacterial agent 237 (0.39 μg/mL, 5-6 h) is not likely to induce S. aureus Newman resistance^[1].
Antibacterial agent 237 (0.78-4.68 μg/mL, 0-6 h) destroys S. aureus Newman cell membranes, produces ROS, causes bacterial contents to leak, and leads to bacterial death^[1].
Antibacterial agent 237 (0-100 μg/mL, 24 h) has a killing effect on S. aureus Newman and does not damage normal cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.