Antibacterial agent 355
Antibacterial agent 355 is a bacterial tRNA (m1G37) methyltransferase (TrmD) inhibitor with an IC50 of 0.85 μM against E. coli. Antibacterial agent 355 shows weak inhibitory activity against human Trm5, with an approximate IC50 of 1.88 mM. Antibacterial agent 355 inhibits the growth of bacterial strains expressing TrmD. Antibacterial agent 355 can be used for the research of bacterial infections.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C28H30N4O3
- 分子量:470.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Antibacterial agent 355 (Compound 16) (100 μM; 2.5 h) inhibits growth of the hyper-permeable E. coli porin mutant strain by 99.3% at a concentration of 100 μM after 2.5 h of incubation at 37 °C[1].
Antibacterial agent 355 (16 h) inhibits growth of the hyper-permeable E. coli porin mutant strain with an MIC of 167 μM after 16 h of incubation at 37 °C[1].
Antibacterial agent 355 (100 μM; 0-8 h) selectively inhibits growth of hyper-permeable bacteria expressing E. coli TrmD, with rapid, near-complete inhibition by 2 h at 100 μM, while showing weaker, slower inhibition of bacteria expressing human Trm5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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分子量 470.56
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分子式 C28H30N4O3
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SMILES
O=C(N)C(C=C1)=CN=C1NCC(C)(C)C2=CC(CNC(/C=C/C(C3=CC=C(C)C=C3)=O)=O)=CC=C2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Antibacterial agent 355 関連分類
HY-184445 関連分類
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