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United States

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製品番号: HY-133135

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CHIKV-IN-1

CHIKV-IN-1 (Compound 3a) is a compound that inhibits the Chikungunya virus (CHIKV) with an EC₅₀ of 0.12 μM. CHIKV-IN-1 is a potent inhibitor of the S-adenosyl-L-homocysteine hydrolase (SAH hydrolase), with an IC₅₀ of 0.36 μM. CHIKV-IN-1 is only effective against CHIKV and some other alphaviruses, but has no activity against other RNA viruses such as SARS-CoV, MERS-CoV, and ZIKV. CHIKV-IN-1 has extremely low cytotoxicity (CC₅₀ > 250 μM), and it has an extremely high selectivity index (SI > 2083). CHIKV-IN-1 can be used in research on anti-Chikungunya virus.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2236598-97-1
分子式: C₁₂H₁₆FN₅O₃
分子量:297.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

CHIKV-IN-1 構造式

CAS 番号: 2236598-97-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	CC₅₀	>250 μM Compound: 3a	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability measured after 96 hrs by MTS assay	[PMID: 31841728]
Vero C1008	EC₅₀	0.12 μM Compound: 3a	Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay Antiviral activity against CHIKV LS3 infected in African green monkey Vero E6 cells assessed as reduction in virus-induced cytopathic effect pretreated with compound followed by viral infection and measured at 96 hrs post-infection by MTS assay	[PMID: 31841728]

化学情報

CAS 番号 2236598-97-1
分子量 297.29
分子式 C₁₂H₁₆FN₅O₃
SMILES

F[C@H]1[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]([C@@H]([C@H]1CCO)O)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Shin YS, et al. Identification of 6'-β-fluoro-homoaristeromycin as a potent inhibitor of chikungunya virus replication. Eur J Med Chem. 2020 Feb 1;187:111956. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

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100 mg

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