COX-2-IN-34
Based on 1 Customer Validation
COX-2-IN-34 (compound 8a) is a selective and orally active inhibitor of COX-2 , with an IC50 of 0.42 μM. COX-2-IN-34 has no gastric ulcer toxicity but has anti-inflammatory effects.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 98.87%
- CAS 番号: 2788578-71-0
- 分子式: C13H11NO4
- 分子量:245.23
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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COX-2 0.42 μM (IC50) |
COX-2-IN-34 (compound 8a) (100 μM, 24 h) shows no obvious cytotoxicity to RAW264.7 cells[1].
Cox-2- IN -34 selectively inhibits the COX-1 and COX-2 activity with IC50 values of 34.86 and 0.42μM, respectively. The inhibition effect of COX-2-IN-34 (10 μM ) on COX-2 reaches 82%[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
COX-2-IN-34 (50 mg/kg for s.c., three times) shows significant anti-inflammatory effects in the Carrageenan-induced rat paw edema assay model [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:The Carrageenan-induced rat paw edema assay model[1]
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Dosage:50 mg/kg
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Administration:Subcutaneous injection (s.c.)
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Result:Expressed the reduction of edema claw volume after 0h, 1 h, 2 h, 3h, 4 h, and 6 h of carrageenan injection compared to the control group.
Exhibited superior inhibition of 42.90% and 45.95% at the 3rd and 4th hour, respectively, which was comparatively much closer in potency to that of the Celecoxib (HY-14398) group (45.18% inhibition of edema at 3h).
化学情報
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CAS 番号 2788578-71-0
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性状 Solid
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分子量 245.23
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分子式 C13H11NO4
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Color Light brown to brown
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SMILES
O=C(NC1=CC=CC=C1O)C2=CC=CC(O)=C2O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 25 mg/mL (101.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.0778 mL | 20.3890 mL | 40.7780 mL | 101.9451 mL |
| 5 mM | 0.8156 mL | 4.0778 mL | 8.1556 mL | 20.3890 mL | |
| 10 mM | 0.4078 mL | 2.0389 mL | 4.0778 mL | 10.1945 mL | |
| 15 mM | 0.2719 mL | 1.3593 mL | 2.7185 mL | 6.7963 mL | |
| 20 mM | 0.2039 mL | 1.0195 mL | 2.0389 mL | 5.0973 mL | |
| 25 mM | 0.1631 mL | 0.8156 mL | 1.6311 mL | 4.0778 mL | |
| 30 mM | 0.1359 mL | 0.6796 mL | 1.3593 mL | 3.3982 mL | |
| 40 mM | 0.1019 mL | 0.5097 mL | 1.0195 mL | 2.5486 mL | |
| 50 mM | 0.0816 mL | 0.4078 mL | 0.8156 mL | 2.0389 mL | |
| 60 mM | 0.0680 mL | 0.3398 mL | 0.6796 mL | 1.6991 mL | |
| 80 mM | 0.0510 mL | 0.2549 mL | 0.5097 mL | 1.2743 mL | |
| 100 mM | 0.0408 mL | 0.2039 mL | 0.4078 mL | 1.0195 mL |
COX-2-IN-34 関連分類
HY-155133 関連分類
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