CP-100356
Based on 9 publication(s) in Google Scholar
CP-100356 is an orally active dual MDR1 (P-gp)/BCRP inhibitor, with an IC50s of 0.5 and 1.5 µM for inhibiting MDR1-mediated Calcein-AM transport and BCRP-mediated Prazosin transport, respectively. CP-100356 is also a weak inhibitor of OATP1B1 (IC50 = ∼66 µM). CP-100356 is devoid of inhibition against MRP2 and major human P450 enzymes (IC50 > 15 µM).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 142716-85-6
- 分子式: C31H36N4O6
- 分子量:560.64
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
MedChemExpress(MCE)の使用を引用している文献 CP-100356
More- J Med Chem. 2024 May 16. [Abstract]
- Commun Med (Lond). 2025 Apr 26;5(1):140. [Abstract]
- Molecules. 2025 Jan 17;30(2):387. [Abstract]
- Antimicrob Agents Chemother. 2025 Apr 2;69(4):e0155624. [Abstract]
- SLAS Discov. 2024 May 16:100160. [Abstract]
- bioRxiv. 2025 Nov 3.
- Res Sq. 2024 Nov 25.
- Preprints. 2024 Jan 3.
- Preprints. 2022, 2022050381.
生物活性
化学情報
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CAS 番号 142716-85-6
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分子量 560.64
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分子式 C31H36N4O6
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SMILES
COC1=CC2=NC(NCCC3=CC=C(C(OC)=C3)OC)=NC(N4CC5=C(CC4)C=C(C(OC)=C5)OC)=C2C=C1OC
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (9)
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Journal Impact Factor
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Most Recent
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J Med Chem
Macrocyclic Azapeptide Nitriles: Structure-Based Discovery of Potent SARS-CoV-2 Main Protease Inhibitors as Antiviral Drugs. [Abstract]2024 May 16. PMID: 38753594 -
Commun Med (Lond)
Targeted protein degraders of SARS-CoV-2 Mpro are more active than enzymatic inhibition alone with activity against nirmatrelvir resistant virus. [Abstract]2025 Apr 26;5(1):140. PMID: 40287552 -
Molecules
Antiviral Activity and Underlying Mechanism of Moslae herba Aqueous Extract for Treating SARS-CoV-2. [Abstract]2025 Jan 17;30(2):387. PMID: 39860255 -
Antimicrob Agents Chemother
Potent antiviral activity of simnotrelvir against key epidemic SARS-CoV-2 variants with a high resistance barrier. [Abstract]2025 Apr 2;69(4):e0155624. PMID: 40062859 -
SLAS Discov
2024 May 16:100160. PMID: 38761981 -
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純度とドキュメンテーション
参考文献
[1]. Kalgutkar AS, et, al. N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat. J Pharm Sci. 2009 Dec;98(12):4914-27. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)