Dasabuvir sodium
Based on 15 publication(s) in Google Scholar
Dasabuvir (ABT-333) sodium is a nonnucleoside hepatitis C virus (HCV) polymerase inhibitor. Dasabuvir sodium inhibits RNA-dependent RNA polymerase encoded by the HCV NS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, with EC50 values of 7.7 and 1.8 nM, respectively.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1132940-11-4
- 分子式: C26H27N3NaO5S
- 分子量:516.56
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Dasabuvir sodium
More- Cell Rep Med. 2026 Mar 9:102646. [Abstract]
- Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):1922-1927. [Abstract]
- Antimicrob Agents Chemother. 2019 May 24;63(6). pii: e00003-19. [Abstract]
- Antiviral Res. 2019 Oct;170:104570. [Abstract]
- Antiviral Res. 2017 Mar;139:18-24. [Abstract]
- Sci Rep. 2020 Feb 26;10(1):3521. [Abstract]
- Sci Rep. 2018 Aug 20;8(1):12469. [Abstract]
- ACS Infect Dis. 2025 Oct 30. [Abstract]
- Viruses. 2017 Jun 16;9(6). pii: E151. [Abstract]
- Toxicol Lett. 2025 Apr:406:31-37. [Abstract]
- Virology. 2023 Aug:585:205-214. [Abstract]
- Biochem Biophys Res Commun. 2023 Jan 22:641:50-56. [Abstract]
- J Liq ChromaTogr R T. 2019: 1-9.
- University of Glasgow. 2024 Mar.
- Chem Cent J. 2017 Jan 3:11:1. [Abstract]
DNA/RNA Synthesis アイソフォーム固有の製品をすべて表示
More
生物活性
|
RNA Polymerase |
Dasabuvir (ABT-333) sodium is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases[1].
Dasabuvir sodium inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM[1].
Dasabuvir sodium inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50 values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 1132940-11-4
-
分子量 516.56
-
分子式 C26H27N3NaO5S
-
SMILES
O=C1C=CN(C2=CC(C(C)(C)C)=C(OC)C(C3=CC=C4C=C(NS(=O)(C)=O)C=CC4=C3)=C2)C(N1)=O.[Na]
-
別名
ABT-333 sodium
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (15)
-
Journal Impact Factor
-
Most Recent
-
Cell Rep Med
Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery. [Abstract]2026 Mar 9:102646. PMID: 41806841 -
Proc Natl Acad Sci U S A
Quantifying antiviral activity optimizes drug combinations against hepatitis C virus infection. [Abstract]2017 Feb 21;114(8):1922-1927. PMID: 28174263 -
Antimicrob Agents Chemother
2019 May 24;63(6). pii: e00003-19. PMID: 30885901 -
Antiviral Res
Antiviral candidates against the hepatitis E virus (HEV) and their combinations inhibit HEV growth in in vitro. [Abstract]2019 Oct;170:104570. PMID: 31362004 -
Antiviral Res
A profiling study of a newly developed HCVcc strain PR63cc's sensitivity to direct-acting antivirals. [Abstract]2017 Mar;139:18-24. PMID: 28025084 -
Sci Rep
Development and validation of UPLC-MS/MS method for studying the pharmacokinetic interaction of dasabuvir and tamoxifen, 4-hydroxytamoxifen in Wistar rats. [Abstract]2020 Feb 26;10(1):3521. PMID: 32103133 -
Sci Rep
HA1077 displays synergistic activity with daclatasvir against hepatitis C virus and suppresses the emergence of NS5A resistance-associated substitutions in mice. [Abstract]2018 Aug 20;8(1):12469. PMID: 30127498 -
ACS Infect Dis
Targeting the Rift Valley Fever Virus Polymerase: Resistance Mechanisms and Structural Insights. [Abstract]2025 Oct 30. PMID: 41166549 -
Viruses
Biophysical Mode-of-Action and Selectivity Analysis of Allosteric Inhibitors of Hepatitis C Virus (HCV) Polymerase. [Abstract]2017 Jun 16;9(6). pii: E151. PMID: 28621755 -
Toxicol Lett
Discovery of non-steroidal aldo-keto reductase 1D1 inhibitors through automated screening and in vitro evaluation. [Abstract]2025 Apr:406:31-37. PMID: 39988211 -
Virology
Structure-based virtual screening of ROCK1 inhibitors for the discovery of Enterovirus-A71 antivirals. [Abstract]2023 Aug:585:205-214. PMID: 37384967 -
Biochem Biophys Res Commun
Sofosbuvir and its tri-phosphate metabolite inhibit the RNA-dependent RNA polymerase activity of non-structural protein 5 from the Kyasanur forest disease virus. [Abstract]2023 Jan 22:641:50-56. PMID: 36521285 -
-
-
Chem Cent J
Simultaneous determination of newly developed antiviral agents in pharmaceutical formulations by HPLC-DAD. [Abstract]2017 Jan 3:11:1. PMID: 28101128
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Powered by Bioz