IFI30 - IFI30 lysosomal thiol reductase Gene

Also Known as GILT; IP30; IP-30; IFI-30

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10437

About IFI30

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:18,173,813-18,178,117 (from NCBI)

This gene has 3 transcripts (splice variants) and 127 orthologues. Broad expression in appendix (RPKM 362.8), lung (RPKM 227.6) and 16 other tissues.

Summary

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in Other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]

IFI30 Products (1)

mRNA Protein Name
NM_006332.5 NP_006323.2 gamma-interferon-inducible lysosomal thiol reductase preproprotein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables oxidoreductase activity, acting on a sulfur group of donors EXP
EXP: Inferred from Experiment
10639150 GOA
enables oxidoreductase activity, acting on a sulfur group of donors IMP
IMP: Inferred from mutant phenotype
10639150 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in lysosome IDA
IDA: Inferred from direct assay
10639150 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IFI30 Protein Structure

GILT

GILT: Gamma interferon inducible lysosomal thiol reductase (GILT) (62 - 164)

  • 0
  • 100
  • 200
  • 250 a.a.
Protein Preferred Names Protein Names

gamma-interferon-inducible lysosomal thiol reductase

  • gamma-interferon-inducible protein IP-30

IFI30 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
IFI30 P13284 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra
IFI30 P13284 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra
IFI30 P13284 TGM1 Homo sapiens P22735
Validated Y2H
32296183
Intra
IFI30 P13284 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
25416956
Intra
IFI30 P13284 KRTAP4-12 Homo sapiens Q9BQ66
Validated Y2H
25416956
Intra
IFI30 P13284 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
IFI30 P13284 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IFI30 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P75820 IFI30 Protein, Human (HEK293, His) P13284 (S27-K232) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Lassa Fever

  • Lf

  • Lassa Hemorrhagic Fever

  • Lf - [Lassa Fever]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06554 IFI30 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19445 Ifi30 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25937 Ifi30 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus IFI30 RGD RGD:1310758
Mus musculus IFI30 MGD MGI:2137648
Felis catus IFI30 VGNC VGNC:67696
Canis familiaris IFI30 VGNC VGNC:41871
Bos taurus IFI30 VGNC VGNC:30043
Others IFI30 NCBI