Hnf1a - HNF1 homeobox A Gene

Also Known as HNF1; LFB1; Tcf1; Hnf-1; Tcf-1; HNF1[a]; Hnf1alpha; HNF1-alpha

生物種: Mus musculus

遺伝子タイプ: protein coding
遺伝子ID: 21405

Summary

This gene encodes a hepatic transcription factor. The encoded protein is not a member of the T-cell factor family, and is distinct from T-cell specific transcription factor 7 which has also been referred to by the symbol Tcf1. [provided by RefSeq, Jul 2008]

Hnf1a Products (1)

mRNA Protein Name
NM_009327.3 NP_033353.2 hepatocyte nuclear factor 1-alpha

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables DNA binding IDA
IDA: Inferred from direct assay
1363228 MGI
enables DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
2044952 MGI
enables DNA-binding transcription factor activity IMP
IMP: Inferred from mutant phenotype
8598044 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
11287626 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
22780989 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
1685988 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
2044952 MGI
enables protein dimerization activity IPI
IPI: Inferred from physical interaction
11106484 MGI
Biological Process GO Annotation Evidence 参考文献 由来
involved in D-glucose import IDA
IDA: Inferred from direct assay
11269503 MGI
acts upstream of or within bile acid and bile salt transport IMP
IMP: Inferred from mutant phenotype
11279518 MGI
acts upstream of or within bile acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
11279518 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
11279518 MGI
acts upstream of or within chromatin remodeling IMP
IMP: Inferred from mutant phenotype
11733582 MGI
involved in chromatin remodeling IMP
IMP: Inferred from mutant phenotype
12367519 MGI
acts upstream of or within fatty acid biosynthetic process IMP
IMP: Inferred from mutant phenotype
10852923 MGI
acts upstream of or within fatty acid transport IMP
IMP: Inferred from mutant phenotype
10852923 MGI
involved in glucose homeostasis IDA
IDA: Inferred from direct assay
11269503 MGI
acts upstream of or within glucose homeostasis IMP
IMP: Inferred from mutant phenotype
9593777 MGI
acts upstream of or within heme biosynthetic process IMP
IMP: Inferred from mutant phenotype
10617683 MGI
acts upstream of or within insulin secretion IMP
IMP: Inferred from mutant phenotype
9566924 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
9566924 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
2044952 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11269503 MGI
acts upstream of or within positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
8598044 MGI
involved in positive regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
12367519 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15581617 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
11287626 MGI
acts upstream of or within regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
9566924 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9689059 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
22589549 MGI
involved in renal D-glucose absorption IDA
IDA: Inferred from direct assay
11269503 MGI
acts upstream of or within reproductive structure development IMP
IMP: Inferred from mutant phenotype
9566924 MGI
acts upstream of or within response to glucose IMP
IMP: Inferred from mutant phenotype
9733737 MGI
acts upstream of or within response to oxidative stress IMP
IMP: Inferred from mutant phenotype
10617683 MGI
acts upstream of or within reverse cholesterol transport IMP
IMP: Inferred from mutant phenotype
15793583 MGI
Cellular Component GO Annotation Evidence 参考文献 由来
located in nucleus IDA
IDA: Inferred from direct assay
1363228 MGI
part of transcription regulator complex IPI
IPI: Inferred from physical interaction
14570708 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatocyte nuclear factor 1-alpha

  • liver-specific transcription factor LF-B1

  • transcription factor 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS06255 HNF1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174669 Human HNF1A mRNA / Unkown
HY-RS19690 Hnf1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26185 Hnf1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Homo sapiens Hnf1a NCBI NCBI:6927