COLGALT2 - collagen beta(1-O)galactosyltransferase 2 Gene

Also Known as C1orf17; GLT25D2; ColGalT 2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 23127

About COLGALT2

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:183,929,662-184,037,728 (from NCBI)

This gene has 5 transcripts (splice variants), 243 orthologues and 5 paralogues. Biased expression in brain (RPKM 11.8), adrenal (RPKM 2.5) and 7 other tissues.

Summary

Predicted to enable procollagen galactosyltransferase activity. Predicted to be involved in Collagen fibril organization. Predicted to be located in endoplasmic reticulum lumen. [provided by Alliance of Genome Resources, Apr 2022]

COLGALT2 Products (3)

mRNA Protein Name
NM_001303420.2 NP_001290349.1 procollagen galactosyltransferase 2 isoform 2 precursor
NM_001303421.2 NP_001290350.1 procollagen galactosyltransferase 2 isoform 3
NM_015101.4 NP_055916.1 procollagen galactosyltransferase 2 isoform 1precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COLGALT2 Protein Structure

Glyco_tranf_2_4

Glyco_tranf_2_4: Glycosyl transferase family 2 (62 - 179)

Glyco_transf_25

Glyco_transf_25: Glycosyltransferase family 25 (LPS biosynthesis protein) (342 - 525)

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  • 500
  • 626 a.a.
Protein Preferred Names Protein Names

procollagen galactosyltransferase 2

  • glycosyltransferase 25 domain containing 2

COLGALT2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
COLGALT2 Q8IYK4 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Prey Pooling
25416956
Intra
COLGALT2 Q8IYK4 HPCAL1 Homo sapiens P37235
Y2H Prey Pooling
32296183
Intra
COLGALT2 Q8IYK4 HPCAL1 Homo sapiens P37235
MAPPIT
32296183
Intra
COLGALT2 Q8IYK4 HPCAL1 Homo sapiens P37235
Y2H Array
32296183
Intra
COLGALT2 Q8IYK4 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
COLGALT2 Q8IYK4 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra
COLGALT2 Q8IYK4 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant COLGALT2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P76954 GLT25D2 Protein, Human (sf9, His) Q8IYK4 (M1-S622) ≥ 85%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Osteogenesis Imperfecta, Type Ix

  • Osteogenesis Imperfecta Type 9

  • Osteogenesis Imperfecta Type Ix

  • OI9

  • Oi Type Ix

  • Osteogenesis Imperfecta Sillence Type Ii/Iii Without Abnormality Of Type I Collagen

  • Oi, Type Ix

  • Oi 9

  • Osteogenesis Imperfecta 9

  • Oi-Ix
Bruck Syndrome

  • Osteogenesis Imperfecta With Congenital Joint Contractures

  • Osteogenesis Imperfecta-Congenital Joint Contractures Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03007 COLGALT2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21272 Colgalt2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27790 Colgalt2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta COLGALT2 VGNC VGNC:99871
Felis catus COLGALT2 VGNC VGNC:107862
Canis familiaris COLGALT2 VGNC VGNC:53337
Mus musculus COLGALT2 MGD MGI:2138232
Rattus norvegicus COLGALT2 RGD RGD:1304702
Others COLGALT2 NCBI