Pde4a - phosphodiesterase 4A Gene

Also Known as DPDE2; PHOSA

生物種: Rattus norvegicus

遺伝子タイプ: protein coding

遺伝子ID: 25638

About Pde4a

Primary_assembly 8: 19,703,290-19,751,961 forward strand.mRatBN7.2:CM026981.1

This gene has 7 transcripts (splice variants), 261 orthologues, 20 paralogues and is associated with 3 phenotypes. Biased expression in Muscle (RPKM 72.2), Heart (RPKM 63.3) and 9 other tissues.

Summary

Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and cAMP binding activity. Involved in modulation of chemical synaptic transmission and response to xenobiotic stimulus. Located in cytosol; nucleus; and perinuclear region of cytoplasm. Is active in Schaffer collateral - CA1 synapse. Biomarker of brucellosis and visual epilepsy. Orthologous to human PDE4A (phosphodiesterase 4A). [provided by Alliance of Genome Resources, Apr 2022]

Pde4a Products (4)

mRNA	Protein	Name
NM_001393737.1	NP_001380666.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4
NM_013101.4	NP_037233.4	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1
NM_001393736.1	NP_001380665.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3
NM_001393735.1	NP_001380664.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	8557632	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12810716	RGD

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cAMP catabolic process	IDA IDA: Inferred from direct assay	8557632	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	27559174	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	27559174	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16190900	RGD

Cellular Component GO Annotation	Evidence	参考文献	由来
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	27559174	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	27559174	RGD
located in cytosol	IDA IDA: Inferred from direct assay	8557632	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15242814	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pde4a Protein Structure

PDE4_UCR

PDEase_I

0
200
400
600
800
844 a.a.

Protein Preferred Names	Protein Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	phosphodiesterase 4A, cAMP specific phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila)

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-B1639	Enoximone	Inhibitor	99.91%	Unkown

Clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Phase
HY-108047	MK-0873	Inhibitor	95.0%	Phase 2
HY-106003	GSK356278	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (13)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-119190	PF-06445974	Inhibitor	98.59%	Unkown
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.91%	Unkown
HY-103050	ML-030	Inhibitor	99.28%	Unkown
HY-131707	LEO 39652	Inhibitor	99.51%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-114052	NVP-ABE171	Inhibitor	/	Unkown
HY-122167	L-869298	Inhibitor	/	Unkown
HY-134937	BC8-15	Inhibitor	/	Unkown
HY-179504	PDE4B-IN-6	Inhibitor	/	Unkown
HY-201403	LY2775240	Inhibitor	/	Unkown
HY-RS10220	PDE4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10221	Pde4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10222	Pde4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Homo sapiens	Pde4a	NCBI	NCBI:5141