PDE4A - phosphodiesterase 4A Gene

Also Known as PDE4; DPDE2; PDE46

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5141

About PDE4A

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,416,773-10,469,631 (from NCBI)

This gene has 9 transcripts (splice variants), 261 orthologues and 20 paralogues. Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 5.3) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE4A Products (13)

mRNA	Protein	Name
NM_001111308.1	NP_001104778.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 2
XM_047438910.1	XP_047294866.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2
XM_047438912.1	XP_047294868.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X4
XM_047438911.1	XP_047294867.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3
XM_047438914.1	XP_047294870.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X7
XM_047438915.1	XP_047294871.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X8
NM_001243121.2	NP_001230050.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5
XM_011528055.4	XP_011526357.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X5
NM_006202.3	NP_006193.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4
NM_001111307.2	NP_001104777.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1
XM_017026865.3	XP_016882354.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1
XM_047438913.1	XP_047294869.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X6
NM_001111309.1	NP_001104779.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	7888306	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables cAMP binding	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11306681	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cAMP catabolic process	IDA IDA: Inferred from direct assay	7888306	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	7888306	GOA
located in extrinsic component of membrane	IDA IDA: Inferred from direct assay	9677330	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11306681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4A Protein Structure

PDEase_I

0
200
400
600
800
864 a.a.

Protein Preferred Names	Protein Names
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	phosphodiesterase 4A, cAMP-specific (dunce phosphodiesterase E2 dunce homolog, Drosophila phosphodiesterase isozyme 4

Related Diseases

Diseases	Alias
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Acrodysostosis	Acrodysplasia Arkless-Graham Syndrome Maroteaux-Malamut Syndrome Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome
Impotence	Erectile Dysfunction Sexual Impotence Erectile Dysfunction Adverse Event
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Disease Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Brain Oligodendroglioma	Oligodendroglioma Of Brain
Psoriatic Arthritis	Psoriatic Arthritis, Susceptibility To Psoriatic Arthropathy Arthropathic Psoriasis Arthritis, Psoriatic Arthritis Psoriatica PSORAS Arthritic Psoriasis Psoriasis Arthropathica Arthritis Psoriatic Arthritis, Psoriatic, Susceptibility To
Skin Disease	Skin Diseases Abnormality Of The Skin Skin Diseases, Genetic Genodermatosis Skin And Subcutaneous Tissue Disease Dermatologic Disorders
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Psoriasis
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Pulmonary Disease, Chronic Obstructive	Chronic Obstructive Pulmonary Disease COPD Pulmonary Disease, Chronic Obstructive, Severe Early-Onset Chronic Obstructive Lung Disease Chronic Obstructive Airway Disease Pulmonary Disease, Chronic Obstructive, Susceptibility To Cold Severe Early-Onset Chronic Obstructive Pulmonary Disease Pulmonary Disease Chronic Obstructive Pulmonary Disease, Obstructive, Chronic, Susceptibility To Chronic Obstructive Pulmonary Disease Of Horses Common Cold Upper Respiratory Infections Copd - [Chronic Obstructive Pulmonary Disease] Coad - [Chronic Obstructive Airways Disease] Cold - [Chronic Obstructive Lung Disease] Chronic Airway Disease Nos Chronic Airways Limitation, Unspecified Chronic Obstructed Airway, Unspecified Chronic Obstructive Airway Disease, Unspecified Chronic Obstructive Airway, Unspecified Obstructive Lung Disease Nos Chronic Obstructive Lung Disease Nos Chronic Obstructive Lung Nos Obstructive Pulmonary Disease Nos Exacerbation Copd Nos Acute Exacerbation Copd
Dermatitis, Atopic	Atopic Dermatitis Atopic Eczema Dermatitis, Atopic, Susceptibility To, 1 Atod Eczema, Atopic Dermatitis, Atopic 1 Allergic Dermatitis Atopic Neurodermatitis Besnier'S Prurigo Dermatitis, Atopic, 1 Dermatitis Atopic Eczema Besnier Prurigo
Respiratory Failure	Acute Respiratory Failure Chronic Respiratory Failure Respiratory Insufficiency Acute-On-Chronic Respiratory Failure Acute And Chronic Respiratory Failure Respiratory Insufficiency/Failure Chronic Respiratory Disease Respiratory Disease Pulmonary Valve Insufficiency Chronic Disease Of Respiratory System Respiration Disorders Respiratory Tract Diseases Lung Failure Nos Pulmonary Failure Arf - [Acute Respiratory Failure] Acute Respiratory Insufficiency Acute Pulmonary Insufficiency Acute Respiration Failure Chronic Respiration Failure
Skin Sarcoidosis	Cutaneous Sarcoidosis Cutaneous Sarcoid Sarcoidosis Of Skin
Ocular Hypotension	Hypotony Of Eye
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Microphthalmia, Isolated 1	Isolated Microphthalmia 1 MCOP1 Mcop Anophthalmia, Clinical, Isolated Microphthalmos, Autosomal Recessive
Nasopharyngitis	Chronic Nasopharyngitis Chronic Rhinopharyngitis
Pulmonary Eosinophilia	Asthmatic Pulmonary Eosinophilia Eosinophilic Lung Infiltrate Weingarten'S Syndrome
Mood Disorder	Mood Disorders Episodic Mood Disorder
Pleurisy
Multiple Sclerosis	MS Multiple Sclerosis, Susceptibility To Disseminated Sclerosis Multiple Sclerosis, Disease Progression, Modifier Of Insular Sclerosis Multiple Sclerosis Modifier Of Disease Progression Multiple Sclerosis, Susceptibility To 1 Multiple Sclerosis, Susceptibility To, 1 Multiple Sclerosis 1 Generalized Multiple Sclerosis Multiple Sclerosis Variant Multiple Sclerosis Susceptibility To Cerebrospinal Sclerosis Generalised Multiple Sclerosis Ms - [Multiple Sclerosis] Disseminated Cerebrospinal Sclerosis Disseminated Multiple Sclerosis Disseminated Nervous System Myelosclerosis Multiple Cerebrospinal Sclerosis Multiple Combined Sclerosis Multiple Sclerosis Generalised Disseminated Brain Sclerosis Disseminated Spinal Sclerosis Insular Brain Sclerosis Miliary Brain Sclerosis Multiple Combined Sclerosis Of Spinal Cord Multiple Ascending Sclerosis Multiple Brain Sclerosis Multiple Sclerosis Of Brain Stem Multiple Sclerosis Of The Brain Stem Multiple Sclerosis Of Cord Sclérose En Plaques Plaque Sclerosis Multiple Sclerosis Of The Spinal Cord
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Autoimmune Disease Of Skin And Connective Tissue
Chromosome 16p13.3 Deletion Syndrome, Proximal	Rubinstein-Taybi Syndrome Broad Thumb-Hallux Syndrome Chromosome 16p13.3 Deletion Syndrome Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion Rubinstein Syndrome Broad Thumbs-Halluces Syndrome Rsts Rubinstein-Taybi Deletion Syndrome Rsts Deletion Syndrome Proximal Chromosome 16p13.3 Deletion Syndrome 16p13.3 Deletion Syndrome Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation Rts
Exercise-Induced Bronchoconstriction	Exercise-Induced Asthma Asthma Exercise-Induced
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Bronchial Disease	Bronchial Diseases Bronchial Disorders Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1639	Enoximone	Inhibitor	99.91%	Unkown

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108047	MK-0873	Inhibitor	95.0%	Phase 2
HY-106003	GSK356278	Inhibitor	99.82%	Phase 1
HY-131707	LEO 39652	Inhibitor	99.40%	Phase 1
HY-201403	LY2775240	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119190	PF-06445974	Inhibitor	98.59%	Unkown
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.91%	Unkown
HY-103050	ML-030	Inhibitor	99.28%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-114052	NVP-ABE171	Inhibitor	/	Unkown
HY-122167	L-869298	Inhibitor	/	Unkown
HY-134937	BC8-15	Inhibitor	/	Unkown
HY-179504	PDE4B-IN-6	Inhibitor	/	Unkown
HY-RS10220	PDE4A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10221	Pde4a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS10222	Pde4a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDE4A	VGNC	VGNC:75915
Canis familiaris	PDE4A	VGNC	VGNC:44353
Mus musculus	PDE4A	MGD	MGI:99558
Rattus norvegicus	PDE4A	RGD	RGD:3279
Bos taurus	PDE4A	VGNC	VGNC:55071
Felis catus	PDE4A	VGNC	VGNC:68758
Others	PDE4A	NCBI