MYH1 - myosin heavy chain 1 Gene

Also Known as MYHa; HEL71; MYHSA1; MyHC-2x; MyHC-2X/D

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 4619

About MYH1

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:10,492,307-10,518,542 (from NCBI)

This gene has 1 transcript (splice variant), 83 orthologues and 43 paralogues. Biased expression in prostate (RPKM 4.3), esophagus (RPKM 3.5) and 2 other tissues.

Summary

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of Myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different Myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development. [provided by RefSeq, Jul 2008]

MYH1 Products (1)

mRNA	Protein	Name
NM_005963.4	NP_005954.3	myosin-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cytoplasmic ribonucleoprotein granule	IDA IDA: Inferred from direct assay	15121898	GOA
part of muscle myosin complex	IDA IDA: Inferred from direct assay	18310078	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYH1 Protein Structure

Myosin_N

Myosin_head

Myosin_tail_1

0
300
600
900
1200
1500
1800
1939 a.a.

Protein Preferred Names	Protein Names
myosin-1	epididymis luminal protein 71

MYH1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MYH1	P12882	KRT13	Homo sapiens	A1A4E9	Validated Y2H	25416956
Intra	MYH1	P12882	CCDC125	Homo sapiens	Q86Z20	Y2H Prey Pooling	32296183
Intra	MYH1	P12882	CCDC125	Homo sapiens	Q86Z20	Validated Y2H	32296183
Intra	MYH1	P12882	CCDC125	Homo sapiens	Q86Z20	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

MYH1 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83782	Fast Myosin Skeletal Heavy chain Antibody(YA3479)	IHC-P, IF-Tissue	Human, Mouse, Rat
HY-P85656	Myosin Heavy Chain Antibody (YA5348)	ICC/IF	Human, Mouse, Rat, FruitFly, Nematode

関連疾患

Diseases	Alias
Myh-Associated Polyposis	Autosomal Recessive Familial Adenomatous Polyposis Autosomal Recessive Multiple Colorectal Adenomas Map Syndrome
Retinitis Pigmentosa 67	RP67 Retinitis Pigmentosa, Type 67
Epilepsy, Idiopathic Generalized 12	EIG12 Epilepsy, Idiopathic Generalized, Susceptibility To, 12 Idiopathic Generalized Epilepsy 12 Susceptibility To Idiopathic Generalized Epilepsy 12 Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 12
Dystonia 9	DYT9 Choreoathetosis/Spasticity, Episodic Episodic Choreoathetosis/Spasticity Cse Choreoathetosis, Paroxysmal, With Episodic Ataxia Choreoathetosis, Kinesigenic, With Episodic Ataxia And Spasticity Paroxysmal Dystonic Choreathetosis With Episodic Ataxia And Spasticity Cse Dystonia-9 Kinesigenic Choreoathetosis With Episodic Ataxia And Spasticity Paroxysmal Choreoathetosis With Episodic Ataxia Dystonia, Type 9
Clubfoot	Congenital Talipes Equinovarus Congenital Clubfoot Congenital Equinovarus Equinovarus Deformity Of Foot Club Foot
Arthrogryposis, Distal, Type 7	Hecht Syndrome Trismus-Pseudocamptodactyly Syndrome Distal Arthrogryposis Type 7 Dutch-Kentucky Syndrome DA7 Hecht-Beals Syndrome Mouth, Inability To Open Completely, And Short Finger-Flexor Tendons Mouth, Inability To Completely Open, And Short Finger-Flexor Tendons Arthrogryposis Distal Type 7 Trismus Pseudocamptodactyly Syndrome Arthrogryposis, Distal, 7
Myopathy, Centronuclear, 1	Autosomal Dominant Centronuclear Myopathy CNM1 Centronuclear Myopathy 1 Ad-Cnm Myopathy, Centronuclear, Autosomal Dominant Myotubular Myopathy, Autosomal Dominant Centronuclear Myopathy, Autosomal, Modifier Of Autosomal Dominant Myotubular Myopathy Dnm2-Related Centronuclear Myopathy Centronuclear Myopathy Autosomal Dominant Myopathies, Structural, Congenital Myopathy, Centronuclear, Type 1
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Muscular Dystrophy, Congenital, Lmna-Related	Congenital Muscular Dystrophy Congenital Muscular Dystrophy Due To Lmna Mutation MDCL L-Cmd Lmna-Related Congenital Muscular Dystrophy Muscular Dystrophy, Congenital Congenital Muscular Dystrophy Lmna-Related Lmna-Related Cmd Cmd Mdc Muscular Dystrophy Congenital Lmna-Related Dystrophy, Muscular, Congenital, Lmna-Related Dystrophy, Muscular, Congenital Hereditary Muscular Dystrophy Congenital Hereditary Muscular Dystrophy Congenital Progressive Muscular Dystrophy Hereditary Progressive Muscular Dystrophy
Distal Arthrogryposis	Arthrogryposis Multiplex Congenita Arthrogryposis Congenital Multiple Arthrogryposis Congenital Arthromyodysplasia Fibrous Ankylosis Of Multiple Joints Guerin-Stern Syndrome Guérin-Stern Syndrome Myodystrophia Fetalis Deformans Otto Syndrome Rocher-Sheldon Syndrome Rossi Syndrome Amc Multiple Congenital Arthrogryposis Arthrogryposis Syndrome Arthrogryposis, Distal Distal Arthrogryposis Syndrome Freeman-Sheldon Syndrome Arthrogryposis, Distal, Type 2b Congenital Multiplex Arthrogryposis Amyoplasia Congenita Congenital Amyoplasia Amc - [Arthrogryposis Multiplex Congenita]
Congenital Fiber-Type Disproportion	Congenital Fiber Type Disproportion Cftdm Congenital Myopathy With Fiber Type Disproportion Cftd Congenital Fiber-Type Disproportion Myopathy Fiber-Type Disproportion Myopathy, Congenital Myopathy, Congenital With Fiber-Type Disproportion
Cardiomyopathy, Familial Hypertrophic, 1	Asymmetric Septal Hypertrophy Familial Hypertrophic Cardiomyopathy Hypertrophic Cardiomyopathy 1 CMH1 Hypertrophic Cardiomyopathy 19 CMH Ventricular Hypertrophy, Hereditary Ash Hypertrophic Subaortic Stenosis, Idiopathic Cardiomyopathy, Familial Hypertrophic Cardiomyopathy, Hypertrophic, 1, Digenic Cardiomyopathy, Familial Hypertrophic 1 Hcm Hereditary Ventricular Hypertrophy Idiopathic Hypertrophic Subaortic Stenosis Hypertrophic Cardiomyopathy Cardiomyopathy, Hypertrophic, Familial Cardiomyopathy, Hypertrophic, 1 Familial Asymmetric Septal Hypertrophy Heritable Hypertrophic Cardiomyopathy Fhc Cardiomyopathy, Hypertrophic, Familial, Type 1
Hypertrophic Cardiomyopathy	Hypertrophic Obstructive Cardiomyopathy Cardiomyopathy, Hypertrophic Cardiomyopathy Hypertrophic Obstructive Cardiomyopathy, Hypertrophic, Familial Idiopathic Myocardial Hypertrophy Idiopathic Hypertrophic Cardiomyopathy Obstructive Idiopathic Hypertrophic Cardiomyopathy Obstructive Cardiomyopathy Idiopathic Hypertrophic Subaortic Stenosis Muscular Subaortic Stenosis Hypertrophic Obstructive Subaortic Stenosis
Myopathy	Muscular Diseases Myopathies
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-148369	U7D-1		99.68%	Unkown
HY-RS08895	MYH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21383	Myh1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27902	Myh1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	MYH1	VGNC	VGNC:99320
Rattus norvegicus	MYH1	RGD	RGD:735061
Mus musculus	MYH1	MGD	MGI:1339711
Bos taurus	MYH1	VGNC	VGNC:55851
Others	MYH1	NCBI