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LACTB2 - lactamase beta 2 Gene

Also Known as CGI-83

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 51110

About LACTB2

Cytogenetic location: 8q13.3 Genomic coordinates (GRCh38): 8:70,637,266-70,669,185 (from NCBI)

This gene has 4 transcripts (splice variants) and 209 orthologues. Broad expression in testis (RPKM 25.7), kidney (RPKM 23.4) and 24 other tissues.

Summary

Enables endoribonuclease activity; single-stranded RNA binding activity; and zinc ion binding activity. Involved in RNA phosphodiester bond hydrolysis, endonucleolytic. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Apr 2022]

LACTB2 Products (1)

mRNA	Protein	Name
NM_016027.3	NP_057111.1	endoribonuclease LACTB2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	26826708	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	26826708	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	26826708	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	26826708	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LACTB2 Protein Structure

Lactamase_B

0
100
200
288 a.a.

Protein Preferred Names	Protein Names
endoribonuclease LACTB2	beta-lactamase-like protein 2

LACTB2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	LACTB2	Q53H82	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956
Intra	LACTB2	Q53H82	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LACTB2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70853	LACTB2 Protein, Human (GST)	Q53H82 (M1-L288)	≥ 90%, as determined by reducing SDS-PAGE.

Diseases	Alias
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07490	LACTB2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20172	Lactb2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26676	Lactb2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Bos taurus	LACTB2	VGNC	VGNC:30765
Macaca mulatta	LACTB2	VGNC	VGNC:74072
Mus musculus	LACTB2	MGD	MGI:2442551
Felis catus	LACTB2	VGNC	VGNC:63186
Rattus norvegicus	LACTB2	RGD	RGD:1307876
Canis familiaris	LACTB2	VGNC	VGNC:42560
Others	LACTB2	NCBI